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      Can Increased Recovery Rates from Coronavirus be explained by Prevalence of ADHD? An Analysis at the US Statewide Level

      research-article
      1 , 2 , 3 , 4
      Journal of Attention Disorders
      SAGE Publications
      COVID-19, ADHD

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          Abstract

          Previous research demonstrates that ADHD is considered a risk factor for COVID-19. The current study attempts to investigate the relationships between infection, mortality and recovery rates from coronavirus and the prevalence of ADHD at the US statewide level. Based on information from 2011 regarding the prevalence of ADHD across the US by state, findings suggest that, while there are no correlations between ADHD and population size, infection and mortality rates from coronavirus, recovery rates (recovery-population ratio) rise with the prevalence of ADHD. Consequently, a possible explanation is that in coping with the disease, ADHD might provide an evolutionary advantage. An example of this phenomenon can be found in the gene that causes sickle-cell disease, which, as a non-dominant gene, helps cope with infection from malaria. If corroborated, research findings may support the conclusion that coronavirus limitations in special educational frameworks for ADHD would not be required or could be relaxed.

          JEL Codes: H75, I12

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          Econometric methods for fractional response variables with an application to 401(k) plan participation rates

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            The rise and fall of malaria in a West African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study.

            A better understanding of the effect of malaria control interventions on vector and parasite populations, acquired immunity, and burden of the disease is needed to guide strategies to eliminate malaria from highly endemic areas. We monitored and analysed the changes in malaria epidemiology in a village community in Senegal, west Africa, over 22 years. Between 1990 and 2012, we did a prospective longitudinal study of the inhabitants of Dielmo, Senegal, to identify all episodes of fever and investigate the relation between malaria host, vector, and parasite. Our study included daily medical surveillance with systematic parasite detection in individuals with fever. We measured parasite prevalence four times a year with cross-sectional surveys. We monitored malaria transmission monthly with night collection of mosquitoes. Malaria treatment changed over the years, from quinine (1990-94), to chloroquine (1995-2003), amodiaquine plus sulfadoxine-pyrimethamine (2003-06), and finally artesunate plus amodiaquine (2006-12). Insecticide-treated nets (ITNs) were introduced in 2008. We monitored 776 villagers aged 0-101 years for 2 378 150 person-days of follow-up. Entomological inoculation rate ranged from 142·5 infected bites per person per year in 1990 to 482·6 in 2000, and 7·6 in 2012. Parasite prevalence in children declined from 87% in 1990 to 0·3 % in 2012. In adults, it declined from 58% to 0·3%. We recorded 23 546 fever episodes during the study, including 8243 clinical attacks caused by Plasmodium falciparum, 290 by Plasmodium malariae, and 219 by Plasmodium ovale. Three deaths were directly attributable to malaria, and two to severe adverse events of antimalarial drugs. The incidence of malaria attacks ranged from 1·50 attacks per person-year in 1990 to 2·63 in 2000, and to only 0·046 in 2012. The greatest changes were associated with the replacement of chloroquine and the introduction of ITNs. Malaria control policies combining prompt treatment of clinical attacks and deployment of ITNs can nearly eliminate parasite carriage and greatly reduce the burden of malaria in populations exposed to intense perennial malaria transmission. The choice of drugs seems crucial. Rapid decline of clinical immunity allows rapid detection and treatment of novel infections and thus has a key role in sustaining effectiveness of combining artemisinin-based combination therapy and ITNs despite increasing pyrethroid resistance. Pasteur Institutes of Dakar and Paris, Institut de Recherche pour le Développement, and French Ministry of Cooperation. Copyright © 2014 Elsevier Ltd. All rights reserved.
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              ADHD as a Risk Factor for Infection With Covid-19

              Background: ADHD limits the ability to comply with Covid-19 prevention recommendations. We hypothesized that ADHD constitutes a risk factor for Covid-19 infection and that pharmacotherapy may lower that risk. Methods: Study population included all subjects ( N  = 14,022) registered with Leumit Health Services between February 1st and April 30, 2020, who underwent at least one Covid-19 test. Data were collected from the electronic health records. Purchasing consecutively at least three ADHD-medication-prescriptions during past year was considered drug-treatment. Results: A total of 1,416 (10.1%) subjects (aged 2 months–103 years) were Covid-19-positive.They were significantly younger, and had higher rates of ADHD (adjOR 1.58 (95% CI 1.27–1.96, p  < .001) than Covid-19-negative subjects. The risk for Covid-19-Positive was higher in untreated-ADHD subjects compared to non-ADHD subjects [crudeOR 1.61 (95% CI 1.36–1.89, p  < .001)], while no higher risk was detected in treated ones [crudeOR 1.07 (95% CI 0.78–1.48, p  = .65)]. Conclusion: Untreated ADHD seems to constitute a risk factor for Covid-19 infection while drug-treatment ameliorates this effect.
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                Author and article information

                Journal
                J Atten Disord
                J Atten Disord
                JAD
                spjad
                Journal of Attention Disorders
                SAGE Publications (Sage CA: Los Angeles, CA )
                1087-0547
                1557-1246
                21 September 2020
                : 1087054720959707
                Affiliations
                [1 ]Western Galilee College, Acre, Israel
                [2 ]Hebrew University of Jerusalem, Mt. Scopus, Jerusalem, Israel
                [3 ]Netanya Academic College, Netanya, Israel
                [4 ]Israel Institute of Technology, Haifa, Israel
                Author notes
                [*]Yuval Arbel, Sir Harry Solomon School of Economics and Management, Western Galilee College, Derech Hamichlala, Acre 2412101, Israel. Emails: YuvalAr@ 123456wgalil.ac.il ; yuval.arbel@ 123456gmail.com
                Author information
                https://orcid.org/0000-0003-4365-6280
                Article
                10.1177_1087054720959707
                10.1177/1087054720959707
                7506183
                32955373
                67eebe83-7931-47ea-b773-e933d8a48b63
                © The Author(s) 2020

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

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