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Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis.
Stefano Ballestri
1 ,
Stefano Zona
2 ,
Giovanni Targher
3 ,
Dante Romagnoli
4 ,
Enrica Baldelli
4 ,
Fabio Nascimbeni
4 ,
Alberto Roverato
5 ,
Giovanni Guaraldi
2 ,
Amedeo Lonardo
4
May 2016
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Abstract
The magnitude of the risk of incident type 2 diabetes (T2D) and metabolic syndrome (MetS) among patients with nonalcoholic fatty liver disease (NAFLD) is poorly known. We gauged the risk of developing T2D and MetS in patients with NAFLD diagnosed by either serum liver enzymes (aminotransferases or gamma-glutamyltransferase [GGT]) or ultrasonography.