CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals (n=30) potentially maintain recognition of the major SARS-CoV-2 variants (n=45 mutations assessed). Only one mutation found in B.1.351-Spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.

Related collections

Author and article information

Journal

Journal ID (nlm-ta): Open Forum Infect Dis

Journal ID (iso-abbrev): Open Forum Infect Dis

Journal ID (publisher-id): ofid

Title: Open Forum Infectious Diseases

Publisher: Oxford University Press (US )

ISSN (Electronic): 2328-8957

Publication date (Electronic): 30 March 2021

Electronic Location Identifier: ofab143

Affiliations

[1 ] Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA

[2 ] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore , MD, USA

[3 ] ImmunoScape Pte Ltd , Singapore

[4 ] Department of Pathology, Johns Hopkins University School of Medicine, Baltimore , MD, USA

[5 ] Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore , MD, USA

Author notes

Corresponding author: Andrew D. Redd, Rangos 540, 851 N Wolfe St, Baltimore MD, 21205, USA, aredd2@ 123456jhmi.edu ; 410-614-0813

Alternative contact: Aaron AR Tobian, Rangos 540, 851 N Wolfe St, Baltimore MD 21205, USA, Atobian1@ 123456jhmi.edu ; 410-614-0813

Author information

Andrew Pekosz https://orcid.org/0000-0003-3248-1761

Article

Publisher ID: ofab143

DOI: 10.1093/ofid/ofab143

PMC ID: 8083629

PubMed ID: 34322559

SO-VID: 6489bda9-f5e5-4a52-8978-e293714664a2

License:

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

History

Date received : 08 March 2021

Custom metadata

article-lifecycle PAP

edited-state accepted-manuscript

Keywords: cd8+ t cell,sars-cov-2,covid-19,convalescent patients

Data availability:

Keywords: cd8+ t cell, sars-cov-2, covid-19, convalescent patients

Comments

Comment on this article

scite_

Cited by 40

See all cited by

- Version 1