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      Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.

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          Abstract

          A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Jan 05 1973
          : 179
          : 4068
          Article
          10.1126/science.179.4068.77
          4682131
          629dbc29-f6a0-4d93-9e56-48ace977455a
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