RNA-based antiviral immunity.

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Abstract

In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) by the host ribonuclease Dicer. After amplification by host RNA-dependent RNA polymerases in some cases, these virus-derived siRNAs guide specific antiviral immunity through RNA interference and related RNA silencing effector mechanisms. Here, I review recent studies on the features of viral siRNAs and other virus-derived small RNAs from virus-infected fungi, plants, insects, nematodes and vertebrates and discuss the innate and adaptive properties of RNA-based antiviral immunity.

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Journal

Journal ID (iso-abbrev): Nat Rev Immunol

Title: Nature reviews. Immunology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1474-1741

ISSN (Print): 1474-1733

Publication date (Electronic): Sep 2010

Volume: 10

Issue: 9

Affiliations

[1 ] Department of Plant Pathology and Microbiology, and Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA. shou-wei.ding@ucr.edu

Article

Publisher Item ID: nri2824

DOI: 10.1038/nri2824

PubMed ID: 20706278

SO-VID: 61d1e6ee-c0cd-47f3-8dce-da5425c2eb15

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