Spot tests: past and present

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Graphic abstract

Microchemistry, i.e., the chemistry performed at the scale of a microgram or less, has its roots in the late eighteenth and early nineteenth centuries. In the first half of the twentieth century a wide range of spot tests have been developed. For didactic reasons, they are still part of the curriculum of chemistry students. However, they are even highly important for applied analyses in conservation of cultural heritage, food science, forensic science, clinical and pharmacological sciences, geochemistry, and environmental sciences. Modern pregnancy tests, virus tests, etc. are the most recent examples of sophisticated spot tests. The present ChemTexts contribution aims to provide an overview of the past and present of this analytical methodology.

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Author and article information

Contributors

María Teresa Doménech-Carbó:

ORCID: http://orcid.org/0000-0003-3660-2161

tdomenec@crbc.upv.es

Journal

Journal ID (nlm-ta): ChemTexts

Journal ID (iso-abbrev): ChemTexts

Title: Chemtexts

Publisher: Springer International Publishing (Cham )

ISSN (Electronic): 2199-3793

Publication date (Electronic): 27 December 2021

Publication date (Print): 2022

Volume: 8

Issue: 1

Electronic Location Identifier: 4

Affiliations

[1 ]GRID grid.157927.f, ISNI 0000 0004 1770 5832, Institut de Restauració del Patrimoni, , Universitat Politècnica de València, ; Camí de Vera 14, 46022 Valencia, Spain

[2 ]GRID grid.5338.d, ISNI 0000 0001 2173 938X, Departament de Química Analítica, , Universitat de València. Dr. Moliner, ; 50, Burjassot, 46100 Valencia, Spain

Author information

María Teresa Doménech-Carbó http://orcid.org/0000-0003-3660-2161

Article

Publisher ID: 152

DOI: 10.1007/s40828-021-00152-z

PMC ID: 8710564

SO-VID: 61979054-dca5-4354-8bcc-e7a0104aecef

License:

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

History

Date received : 15 June 2021

Date accepted : 11 October 2021

Funding

Funded by: FundRef http://dx.doi.org/10.13039/100014440, Ministerio de Ciencia, Innovación y Universidades;

Award ID: PID2020-113022GB-I00

Funded by: FundRef http://dx.doi.org/10.13039/501100011033, Agencia Estatal de Investigación;

Award ID: PID2020-113022GB-I00

Custom metadata

Keywords: spot tests,microchemistry,chemical microscopy,dipstick immunoassay,elisa,microfluidics,µpad,lab-on-a-chip,multiplexed tests,smartphone spectroscopy

Data availability:

Keywords: spot tests, microchemistry, chemical microscopy, dipstick immunoassay, elisa, microfluidics, µpad, lab-on-a-chip, multiplexed tests, smartphone spectroscopy

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