- Record: found
- Abstract: found
- Article: found
Critical role of AMPK in redox regulation under glucose starvation
review-article
02 March 2019
Reactive oxygen species,
Glucose metabolism,
Fatty acid metabolism,
AMPK,
Cancer,
2DG, 2-deoxyglucose,
2DG-6P, 2-deoxyglucose 6-phosphate,
3PG, 3-phosphoglyceric acid,
5TG, 5-thioglucose,
6P-2DG, 6-phospho 2-deoxygluconate,
6P-G, 6-phosphogluconate,
6PGD, 6-phosphogluconate dehydrogenase,
α-KG, α-ketoglutaric acid,
ACC, acetyl-CoA carboxylase,
AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide,
AMPK, 5′ AMP-activated protein kinase,
ARE, antioxidant response,
BRAF, B-Raf proto-oncogene,
CaMKKβ, calcium/calmodulin-dependent protein kinase kinase β,
CAT, catalase,
COX-2, cyclooxygenase-2,
CPT1, carnitine palmitoyltransferase 1,
CRC, colorectal cancer,
CRM, calorie restriction mimetic,
DHA, dehydroascorbic acid,
ECM, extracellular matrix,
ERK2, extracellular signal-regulated kinase 2,
ETC, electron transport chain,
FADH2, the quinone form flavin adenine dinucleotide,
FAS, fatty acid synthesis,
FASN, fatty acid synthase,
FAO, fatty acid oxidation,
G-6P, glucose 6-phosphate,
G6PD, glucose-6-phosphate dehydrogenase,
GAPDH, glyceraldehyde-3-phosphate dehydrogenase,
Glc, glucose,
GLUT1, glucose transporter 1,
GPx, glutathione peroxidase,
GR, glutathione reductase,
GSH, reduced glutathione,
GSSG, oxidized glutathione,
HIF-1α, hypoxia-inducible factor 1-α,
HK, hexokinase,
HNE, 4-hydroxy-2-nonenal,
HO-1, heme oxygenase 1,
IDH, isocitrate dehydrogenase,
LKB1, liver kinase B1,
KEAP1, Kelch-like ECH-associated protein 1,
KO, knockout,
KRAS, Kirsten rat sarcoma,
MAGE A3/6, melanoma-associated antigen 3/6,
MAPK, mitogen-activated protein kinase,
ME, malic enzyme,
MEF, mouse embryonic fibroblasts,
MEK, MAPK Kinase,
mTOR, the mechanistic target of rapamycin,
mTORC1, mTOR Complex 1,
MTP, mitochondrial trifunctional protein,
NAC, N-acetyl cysteine,
NADH, the reduced nicotinamide adenine dinucleotide,
NADP+, nicotinamide adenine dinucleotide phosphate,
NADPH, reduced nicotinamide adenine dinucleotide phosphate,
NQO1, NADPH dehydrogenase (quinone 1),
NOX, NADPH oxidases,
NRF2, nuclear factor (erythroid-derived 2)-like 2,
NSCLC, non-small cell lung cancer,
OXPHOS, oxidative phosphorylation,
PDAC, pancreatic ductal adenocarcinoma,
PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1-α,
PI3K, phosphoinositide-3-kinase,
PPAR, peroxisome proliferator-activated receptor,
PPP, the pentose phosphate pathway,
PTEN, phosphatase and tensin homolog,
R-5P, ribose 5-phosphate,
RAPTOR, regulatory-associated protein of mammalian target of rapamycin,
ROS, reactive oxygen species,
SCD1, stearoyl-CoA desaturase-1,
SGLT2, sodium/glucose cotransporter 2,
SOD, superoxide dismutase,
SREBP, sterol regulatory element binding protein,
TCA, tricarboxylic acid cycle,
TP, trifunctional protein,
TRIM28, tripartite motif-containing 28,
Trx, thioredoxin,
TSC2, tuberous sclerosis complex 2,
UBE2O, (E3-independent) E2 ubiquitin-conjugating enzyme,
UCP2, mitochondrial uncoupling protein 2,
ULK1, UNC-51-like kinase 1
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Abstract
Glucose starvation is one of the major forms of metabolic stress in cancer cells. Deprivation of glucose impairs glycolysis and the pentose phosphate pathway, which elicits oxidative stress due to enhanced production of reactive oxygen species (ROS) and impaired antioxidant system, leading to redox imbalance and cell death. Under glucose starvation, the 5′ AMP-activated protein kinase (AMPK) plays a critical role in maintaining redox homeostasis and cell survival via multiple pathways, such as regulation of fatty acid metabolism and antioxidant response. Convergence of ROS and the glucose metabolic pathway reveals novel molecular targets for the development of effective cancer therapeutic strategies. Interestingly, AMPK, along with its upstream kinase liver kinase B1 (LKB1), has been regarded to play a tumor suppressor role. However, emerging studies have provided novel insights into the pro-tumor survival function of the LKB1-AMPK pathway. Therefore, targeting metabolic and oxidative stress in cancer cells, with manipulation of AMPK activity, is a promising strategy in developing novel cancer therapeutic agents.
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Most cited references47
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- Article: not found
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Author and article information
reactive oxygen species,glucose metabolism,fatty acid metabolism,ampk,cancer,2dg, 2-deoxyglucose,2dg-6p, 2-deoxyglucose 6-phosphate,3pg, 3-phosphoglyceric acid,5tg, 5-thioglucose,6p-2dg, 6-phospho 2-deoxygluconate,6p-g, 6-phosphogluconate,6pgd, 6-phosphogluconate dehydrogenase,α-kg, α-ketoglutaric acid,acc, acetyl-coa carboxylase,aicar, 5-aminoimidazole-4-carboxamide ribonucleotide,ampk, 5′ amp-activated protein kinase,are, antioxidant response,braf, b-raf proto-oncogene,camkkβ, calcium/calmodulin-dependent protein kinase kinase β,cat, catalase,cox-2, cyclooxygenase-2,cpt1, carnitine palmitoyltransferase 1,crc, colorectal cancer,crm, calorie restriction mimetic,dha, dehydroascorbic acid,ecm, extracellular matrix,erk2, extracellular signal-regulated kinase 2,etc, electron transport chain,fadh2, the quinone form flavin adenine dinucleotide,fas, fatty acid synthesis,fasn, fatty acid synthase,fao, fatty acid oxidation,g-6p, glucose 6-phosphate,g6pd, glucose-6-phosphate dehydrogenase,gapdh, glyceraldehyde-3-phosphate dehydrogenase,glc, glucose,glut1, glucose transporter 1,gpx, glutathione peroxidase,gr, glutathione reductase,gsh, reduced glutathione,gssg, oxidized glutathione,hif-1α, hypoxia-inducible factor 1-α,hk, hexokinase,hne, 4-hydroxy-2-nonenal,ho-1, heme oxygenase 1,idh, isocitrate dehydrogenase,lkb1, liver kinase b1,keap1, kelch-like ech-associated protein 1,ko, knockout,kras, kirsten rat sarcoma,mage a3/6, melanoma-associated antigen 3/6,mapk, mitogen-activated protein kinase,me, malic enzyme,mef, mouse embryonic fibroblasts,mek, mapk kinase,mtor, the mechanistic target of rapamycin,mtorc1, mtor complex 1,mtp, mitochondrial trifunctional protein,nac, n-acetyl cysteine,nadh, the reduced nicotinamide adenine dinucleotide,nadp+, nicotinamide adenine dinucleotide phosphate,nadph, reduced nicotinamide adenine dinucleotide phosphate,nqo1, nadph dehydrogenase (quinone 1),nox, nadph oxidases,nrf2, nuclear factor (erythroid-derived 2)-like 2,nsclc, non-small cell lung cancer,oxphos, oxidative phosphorylation,pdac, pancreatic ductal adenocarcinoma,pgc-1α, peroxisome proliferator-activated receptor γ coactivator 1-α,pi3k, phosphoinositide-3-kinase,ppar, peroxisome proliferator-activated receptor,ppp, the pentose phosphate pathway,pten, phosphatase and tensin homolog,r-5p, ribose 5-phosphate,raptor, regulatory-associated protein of mammalian target of rapamycin,ros, reactive oxygen species,scd1, stearoyl-coa desaturase-1,sglt2, sodium/glucose cotransporter 2,sod, superoxide dismutase,srebp, sterol regulatory element binding protein,tca, tricarboxylic acid cycle,tp, trifunctional protein,trim28, tripartite motif-containing 28,trx, thioredoxin,tsc2, tuberous sclerosis complex 2,ube2o, (e3-independent) e2 ubiquitin-conjugating enzyme,ucp2, mitochondrial uncoupling protein 2,ulk1, unc-51-like kinase 1
reactive oxygen species, glucose metabolism, fatty acid metabolism, ampk, cancer, 2dg, 2-deoxyglucose, 2dg-6p, 2-deoxyglucose 6-phosphate, 3pg, 3-phosphoglyceric acid, 5tg, 5-thioglucose, 6p-2dg, 6-phospho 2-deoxygluconate, 6p-g, 6-phosphogluconate, 6pgd, 6-phosphogluconate dehydrogenase, α-kg, α-ketoglutaric acid, acc, acetyl-coa carboxylase, aicar, 5-aminoimidazole-4-carboxamide ribonucleotide, ampk, 5′ amp-activated protein kinase, are, antioxidant response, braf, b-raf proto-oncogene, camkkβ, calcium/calmodulin-dependent protein kinase kinase β, cat, catalase, cox-2, cyclooxygenase-2, cpt1, carnitine palmitoyltransferase 1, crc, colorectal cancer, crm, calorie restriction mimetic, dha, dehydroascorbic acid, ecm, extracellular matrix, erk2, extracellular signal-regulated kinase 2, etc, electron transport chain, fadh2, the quinone form flavin adenine dinucleotide, fas, fatty acid synthesis, fasn, fatty acid synthase, fao, fatty acid oxidation, g-6p, glucose 6-phosphate, g6pd, glucose-6-phosphate dehydrogenase, gapdh, glyceraldehyde-3-phosphate dehydrogenase, glc, glucose, glut1, glucose transporter 1, gpx, glutathione peroxidase, gr, glutathione reductase, gsh, reduced glutathione, gssg, oxidized glutathione, hif-1α, hypoxia-inducible factor 1-α, hk, hexokinase, hne, 4-hydroxy-2-nonenal, ho-1, heme oxygenase 1, idh, isocitrate dehydrogenase, lkb1, liver kinase b1, keap1, kelch-like ech-associated protein 1, ko, knockout, kras, kirsten rat sarcoma, mage a3/6, melanoma-associated antigen 3/6, mapk, mitogen-activated protein kinase, me, malic enzyme, mef, mouse embryonic fibroblasts, mek, mapk kinase, mtor, the mechanistic target of rapamycin, mtorc1, mtor complex 1, mtp, mitochondrial trifunctional protein, nac, n-acetyl cysteine, nadh, the reduced nicotinamide adenine dinucleotide, nadp+, nicotinamide adenine dinucleotide phosphate, nadph, reduced nicotinamide adenine dinucleotide phosphate, nqo1, nadph dehydrogenase (quinone 1), nox, nadph oxidases, nrf2, nuclear factor (erythroid-derived 2)-like 2, nsclc, non-small cell lung cancer, oxphos, oxidative phosphorylation, pdac, pancreatic ductal adenocarcinoma, pgc-1α, peroxisome proliferator-activated receptor γ coactivator 1-α, pi3k, phosphoinositide-3-kinase, ppar, peroxisome proliferator-activated receptor, ppp, the pentose phosphate pathway, pten, phosphatase and tensin homolog, r-5p, ribose 5-phosphate, raptor, regulatory-associated protein of mammalian target of rapamycin, ros, reactive oxygen species, scd1, stearoyl-coa desaturase-1, sglt2, sodium/glucose cotransporter 2, sod, superoxide dismutase, srebp, sterol regulatory element binding protein, tca, tricarboxylic acid cycle, tp, trifunctional protein, trim28, tripartite motif-containing 28, trx, thioredoxin, tsc2, tuberous sclerosis complex 2, ube2o, (e3-independent) e2 ubiquitin-conjugating enzyme, ucp2, mitochondrial uncoupling protein 2, ulk1, unc-51-like kinase 1
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