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      Synthesis, radiolabeling, and preclinical in vivo evaluation of 68Ga-radiolabelled nanodiamonds.

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          Abstract

          Nanodiamonds (NDs) represent a new class of nanoparticles and have gained increasing interest in medical applications. Modifying the surface coating by attaching binding ligands or imaging probes can transform NDs into multi-modal targeting probes. This study evaluated the biokinetics and biodistribution of 68Ga-radiolabelled NDs in a xenograft model.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Nucl Med Biol
          Title: Nuclear medicine and biology
          Publisher: Elsevier BV
          ISSN (Electronic): 1872-9614
          ISSN (Print): 0969-8051
          Publication date (Electronic): 2023
          Volume: 116-117
          Affiliations
          [1 ] Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
          [2 ] Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
          [3 ] Max Planck Institute for Polymer Research, Synthesis of Macromolecules, Mainz, Germany; Institute of Inorganic Chemistry I, Ulm University, Ulm, Germany.
          [4 ] Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
          [5 ] Department of Nuclear Medicine, Ulm University Medical Center, Ulm, Germany(.).
          [6 ] Leibniz-Institute of Surface Engineering (IOM), Leipzig, Germany.
          [7 ] Core Facility Small Animal Imaging, Ulm University, Ulm, Germany.
          [8 ] Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria; Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria. Electronic address: claudia.kuntner@meduniwien.ac.at.
          Article
          Publisher Item ID: S0969-8051(22)02304-6
          DOI: 10.1016/j.nucmedbio.2022.108310
          PubMed ID: 36565646
          SO-VID: 5e0f08d0-bcfa-4c32-bf57-e4bd69f70346
          History

          Keywords: Nanodiamonds,Radiolabeling,Small animal PET
          Data availability:
          Keywords: Nanodiamonds, Radiolabeling, Small animal PET

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