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      Review on Silver Nanoparticle Synthesis Method, Antibacterial Activity, Drug Delivery Vehicles, and Toxicity Pathways: Recent Advances and Future Aspects

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          Abstract

          Silver nanoparticles in the range from 1 to 100 nm are widely used in industrial applications as catalysis, electronics, and photonics, and they have unique properties such as optical, electrical, and magnetic characteristics that can be used as antimicrobial, biosensor textile, cosmetics, composite fibers, and electronic components and to amend shelf life of food substances. The main objective of the present review was to focus on formulation methods of silver nanoparticles with recent advances and future aspects. Silver nanoparticle shows very high potential towards biological applications. Several physicals, chemical, and various biological techniques have been employed to synthesize and stabilize silver nanoparticles. For the manufacture of silver nanoparticles, multiple methods, including chemical simplification with different natural and inorganic decreasing agents, physicochemical reduction, electrochemical procedures, and radiolysis, are employed. Silver nanoparticles are the single most manufacturer-identified material that can be used in all nanotechnology products. They can be used in food packing polymers to enhance the shelf lifespan. The present review is aimed at different types of synthesis and details of silver nanoparticles used as drug delivery vehicles, antibacterial activity, toxicity, recent advances, and future aspects.

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          The bactericidal effect of silver nanoparticles.

          Nanotechnology is expected to open new avenues to fight and prevent disease using atomic scale tailoring of materials. Among the most promising nanomaterials with antibacterial properties are metallic nanoparticles, which exhibit increased chemical activity due to their large surface to volume ratios and crystallographic surface structure. The study of bactericidal nanomaterials is particularly timely considering the recent increase of new resistant strains of bacteria to the most potent antibiotics. This has promoted research in the well known activity of silver ions and silver-based compounds, including silver nanoparticles. The present work studies the effect of silver nanoparticles in the range of 1-100 nm on Gram-negative bacteria using high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM). Our results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
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            Silver nanoparticles as a new generation of antimicrobials.

            Silver has been in use since time immemorial in the form of metallic silver, silver nitrate, silver sulfadiazine for the treatment of burns, wounds and several bacterial infections. But due to the emergence of several antibiotics the use of these silver compounds has been declined remarkably. Nanotechnology is gaining tremendous impetus in the present century due to its capability of modulating metals into their nanosize, which drastically changes the chemical, physical and optical properties of metals. Metallic silver in the form of silver nanoparticles has made a remarkable comeback as a potential antimicrobial agent. The use of silver nanoparticles is also important, as several pathogenic bacteria have developed resistance against various antibiotics. Hence, silver nanoparticles have emerged up with diverse medical applications ranging from silver based dressings, silver coated medicinal devices, such as nanogels, nanolotions, etc.
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              Antimicrobial effects of silver nanoparticles.

              The antimicrobial effects of silver (Ag) ion or salts are well known, but the effects of Ag nanoparticles on microorganisms and antimicrobial mechanism have not been revealed clearly. Stable Ag nanoparticles were prepared and their shape and size distribution characterized by particle characterizer and transmission electron microscopic study. The antimicrobial activity of Ag nanoparticles was investigated against yeast, Escherichia coli, and Staphylococcus aureus. In these tests, Muller Hinton agar plates were used and Ag nanoparticles of various concentrations were supplemented in liquid systems. As results, yeast and E. coli were inhibited at the low concentration of Ag nanoparticles, whereas the growth-inhibitory effects on S. aureus were mild. The free-radical generation effect of Ag nanoparticles on microbial growth inhibition was investigated by electron spin resonance spectroscopy. These results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
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                Author and article information

                Contributors
                (View ORCID Profile)
                (View ORCID Profile)
                Journal
                Journal of Nanomaterials
                Journal of Nanomaterials
                Hindawi Limited
                1687-4129
                1687-4110
                September 25 2021
                September 25 2021
                : 2021
                : 1-11
                Affiliations
                [1 ]Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India
                [2 ]TIFAC, CORE-HD, Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Nilgiris, Ooty, Tamil Nadu, India
                [3 ]Pacemach Tech Consultants, London, UK
                [4 ]Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Nilgiris, Ooty, Tamil Nadu, India
                [5 ]Department of Pharmaceutical, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India
                [6 ]Department of Physics, College of Natural and Computational Science, Dambi Dollo University, Ethiopia
                [7 ]Centre for Excellence-Indigenous Knowledge, Innovative Technology Transfer and Entrepreneurship, Dambi Dollo University, Ethiopia
                [8 ]Department of Mechanical Engineering, ULTRA College of Engineering and Technology, Madurai, 625104 Tamilnadu, India
                [9 ]Department of Chemistry, Sri Venkateswara College of Engineering and Technology, 517004, Chittoor, Andhra Pradesh, India
                [10 ]Department of Mechanical Engineering, College of Engineering and Technology, Dambi Dollo University, Ethiopia
                Article
                10.1155/2021/4401829
                5928d79a-59ef-4e65-ba39-2035734deb7b
                © 2021

                https://creativecommons.org/licenses/by/4.0/

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