Pyrido[2,3- d]pyrimidin-7(8 H)-ones: Synthesis and Biomedical Applications

Abstract

Pyrido[2,3- d]pyrimidines ( 1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3- d]pyrimidine-7(8 H)-ones ( 2) due to the similitude with nitrogen bases present in DNA and RNA. Currently there are more than 20,000 structures 2 described which correspond to around 2900 references (half of them being patents). Furthermore, the number of references containing compounds of general structure 2 have increased almost exponentially in the last 10 years. The present review covers the synthetic methods used for the synthesis of pyrido[2,3- d]pyrimidine-7(8 H)-ones ( 2), both starting from a preformed pyrimidine ring or a pyridine ring, and the biomedical applications of such compounds.