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      Anthocyanins: Promising Natural Products with Diverse Pharmacological Activities

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          Abstract

          Anthocyanins are natural products that give color to plants. As natural plant pigments, anthocyanins also have a series of health-promoting benefits. Many researchers have proved that anthocyanins have therapeutic effects on diseases, such as circulatory, nervous, endocrine, digestive, sensory, urinary and immune systems. Additionally, a large number of studies have reported that anthocyanins have an anticancer effect through a wide range of anti-inflammatory and antioxidant effects. The anti-disease impact and mechanism of anthocyanins are diverse, so they have high research value. This review summarizes the research progress of anthocyanins on the pharmacological agents of different diseases to provide references for subsequent research.

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          Chemical studies of anthocyanins: A review

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            Th17 and regulatory T cell balance in autoimmune and inflammatory diseases.

            This review focuses on the biology of T helper 17 (Th17) and regulatory T (Treg) cells and their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro-inflammatory subset whereas Treg cells have an antagonist effect. Their developmental pathways are reciprocally interconnected and there is an important plasticity between Th17 and Treg cells. These features implicate that the Th17/Treg balance plays a major role in the development and the disease outcomes of animal model and human autoimmune/inflammatory diseases. During these diseases, this balance is disturbed and this promotes the maintenance of inflammation. Targeting the Th17/Treg imbalance can be performed at different levels such as inhibition of pro-inflammatory cytokines and their receptors, of pathogenic cells or their specific signaling pathways. Conversely, direct effects include administration or induction of protective cells, or stimulation of their specific pathways. Several clinical trials are underway and some positive results have been obtained. Copyright © 2014 Elsevier B.V. All rights reserved.
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              Diagnosis and Treatment of Alcohol‐Related Liver Diseases: 2019 Practice Guidance from the American Association for the Study of Liver Diseases

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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                Molecules
                Molecules
                molecules
                Molecules
                MDPI
                1420-3049
                22 June 2021
                July 2021
                : 26
                : 13
                : 3807
                Affiliations
                [1 ]Department of Pharmacy, Baotou Medical College, Baotou 014040, China; ljq15164771109@ 123456163.com (J.L.); zhouhongbing212@ 123456126.com (H.Z.); 102006095@ 123456btmc.edu.cn (M.Q.)
                [2 ]Institute of Bioactive Substance and Function of Mongolian Medicine and Chinese Materia Medica, Baotou Medical College, Baotou 014060, China; hhhtsongli@ 123456126.com (L.S.); yzj8330@ 123456163.com (Z.Y.)
                Author notes
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0002-9160-0401
                https://orcid.org/0000-0002-3110-3892
                Article
                molecules-26-03807
                10.3390/molecules26133807
                8270296
                34206588
                538fd1d6-f58e-4851-9833-bfe88936a6e3
                © 2021 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                : 24 May 2021
                : 15 June 2021
                Categories
                Review

                anthocyanin,natural products,systemic diseases,anticancer,anti-infection

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