The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814–1869) in January 1843

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Abstract

Lactic acid was first found and described in sour milk by Karl Wilhelm Scheele (1742–1786) in 1780. The German physician–chemist Johann Joseph Scherer (1841–1869) demonstrated the occurrence of lactic acid in human blood under pathological conditions in 1843 and 1851. In this article we honour the forgotten observations by Scherer and describe the influence of Scherer's finding on further research on lactic acid at the end of the 19th century. We conclude that Scherer's 1843 case reports should be cited as the first description of lactic acid in human blood after death and also as the first demonstration of lactic acid as a pathological finding in septic and haemorrhagic shock. Carl Folwarczny was, in 1858, the first to demonstrate lactic acid in blood in a living patient.

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Most cited references 31

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Increased blood lacate levels: an important warning signal in surgical practice

Jan Bakker, Alex Pinto de Lima (2004)

Both in emergency and elective surgical patients increased blood lactate levels warn the physician that the patient is at risk of increased morbidity and decreased changes of survival. Prompt therapeutic measures to restore the balance between oxygen demand and supply are warranted in these patients.

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Lactic acid in amphibian muscle.

Alison W Fletcher (1907)

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Validation of a hand-held lactate device in determination of blood lactate in critically injured patients.

B L Bachl, Brian M. Slomovitz, B Tortella … (1998)

Admission blood lactate is an accurate predictor of injury severity and mortality in trauma patients. The purpose of this study was to evaluate a portable lactate analyzer in a clinical setting by patient care staff. A prospective, single-operator control solution and patient sample study, using two test devices and a reference device. An urban Level I trauma center. A convenience sample of 47 trauma patients. Intra-assay precision was demonstrated by performance of consecutive analyses of two lactate control solutions (high and low lactate control concentrations) by medical students and physicians. Split sample, simultaneous testing of the portable lactate analyzer was then performed on 66 whole blood specimens from a convenience sample of 47 trauma patients admitted to an urban Level 1 trauma center over 4 mos. Samples were tested simultaneously tested on two portable lactate analyzers and a reference instrument. Acceptable intra-assay precision was achieved. Regression analysis for two test instruments demonstrated a slope of 0.920, an intercept of 0.323, an r2 of .982, and an SEM of 0.496. Regression analysis for test instrument "A" vs. the reference instrument showed a slope of 0.861, an intercept of 0.209, an r2 of .977, and an SEM of 0.598. Regression analysis for test instrument "B" vs. the reference instrument demonstrated a slope of 0.929, an intercept of -0.095, an r2 of .983, and an SEM of 0.506. Good correlation with a low SEM was obtained over a wide range of clinically relevant lactate values. Use of point of care lactate analysis will decrease analytic time, making an important diagnostic parameter immediately available in the critical care setting.

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Author and article information

Contributors

: e.j.o.kompanje@erasmusmc.nl

Journal

Journal ID (nlm-ta): Intensive Care Med

Title: Intensive Care Medicine

Publisher: Springer-Verlag (Berlin/Heidelberg )

ISSN (Print): 0342-4642

ISSN (Electronic): 1432-1238

Publication date (Electronic): 28 July 2007

Publication date (Print): November 2007

Volume: 33

Issue: 11

Pages: 1967-1971

Affiliations

Department of Intensive Care, Erasmus MC University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands

Article

Publisher ID: 788

DOI: 10.1007/s00134-007-0788-7

PMC ID: 2040486

PubMed ID: 17661014

SO-VID: 511d158b-0c6d-4b21-913b-6552bc074388

History

Date received : 14 April 2007

Date accepted : 28 June 2007

Custom metadata

ScienceOpen disciplines: Emergency medicine & Trauma

Keywords: lactic acid,leukaemia,lactate,johann joseph scherer,shock,historical article

Data availability:

ScienceOpen disciplines: Emergency medicine & Trauma

Keywords: lactic acid, leukaemia, lactate, johann joseph scherer, shock, historical article

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