In the past few months, the world seems to have come to a virtual standstill. As the
SARS-CoV-2 virus continues to spread across the globe, many countries have taken drastic
measures to slow down infection rates. These include social distancing, and in some
countries a complete lock-down of social and economic life. The impact of the corona
virus disease (COVID-19) crisis is evident, on the lives of the worst affected families,
our healthcare systems, and the world economy. There are particular concerns around
the increased vulnerability of patients living with a chronic disease, and this also
includes neurological conditions like Parkinson’s disease (PD). Indeed, PD is more
common in the elderly, and PD can compromise the respiratory system, as reflected
among others by the increased risk of pneumonia that is present in patients with advanced
PD. Although documented reports are thus far lacking, it is conceivable that having
a diagnosis of PD is a risk factor for worse respiratory complications or even an
unfavorable outcome after a COVID-19 infection. This “immediate” impact of a COVID-19
infection for people living with PD has been addressed extensively, among others in
webinars and informative websites issued by patient organizations around the globe
(for examples, see [1]). However, the potential impact of COVID-19 infections for
PD patients extends well beyond these direct threats. Here, we will focus on several
less visible—but also potentially grave—consequences of the COVID-19 pandemic for
people living with PD, and more specifically, on how the preventive social measures
to mitigate the risk of becoming infected have drastically changed the way of life
for many affected persons. We also address how this crisis is already beginning to
lead to new initiatives that offer help and support for patients and their near ones.
The COVID-19 pandemic has profoundly changed people’s normal routines, and this all
happened over a very short period. Such drastic changes require a flexible adaptation
to new circumstances, which is a cognitive operation that depends on normal dopaminergic
functioning. A large body of literature has shown that many PD patients experience
cognitive and motor inflexibility, as a result of nigrostriatal dopamine depletion
that forms the pathophysiological substrate of PD [2, 3]. Furthermore, it has been
hypothesized that dopamine-dependent adaptation is a requirement for successful coping
that, when deficient, leads to a sense of loss of control and increased psychological
stress [4]. This may explain why stress-related psychiatric symptoms such as anxiety
and depression are so common in PD, occurring in up to 30–40% of patients, even outside
times of crisis [5]. Thus, the pathophysiology of PD puts patients at increased risk
of chronic stress, and a further worsening of this may well be one of various hidden
sorrows of the COVID-19 pandemic. Importantly, increased levels of stress during the
COVID-19 pandemic may have several short-term as well as long-term adverse consequences
for individuals with PD. First, increased psychological stress can temporarily worsen
various motor symptoms, such as tremor, freezing of gait or dyskinesias [6–9], while
it reduces the efficacy of dopaminergic medication [6]. Second, increased stress may
unmask a latent hypokinetic rigid syndrome, possibly by depleting compensatory mechanisms
[10, 11]. This could lead to an increase in numbers of new PD diagnoses during the
pandemic. In a year from now, it might be worthwhile to investigate incidence levels
of PD during this time of crisis, as compared to the period before. Third, animal
studies have shown that prolonged episodes of chronic stress may worsen the rate of
dopaminergic cell loss in response to a toxin [12]. Comparable studies in human patients
are lacking, so it remains presently unclear whether chronic stress can actually accelerate
PD. It would be interesting to test this hypothesis, in ongoing longitudinal cohort
studies such as the Parkinson’s Progression Markers Initiative (PPMI) [13], the Oxford
Parkinson’s Disease Centre (OPDC) Discovery Cohort [14], or the Personalized Parkinson
Project (PPP) [15], examining whether the COVID-19 crisis is associated with changes
in biological or clinical progression markers of PD that hint at an acceleration of
the underlying disease process. Interestingly, there are also factors that protect
against the detrimental effects of stress. This has been termed “resilience”, i.e.
the ability to maintain or quickly recover mental health during and after times of
adversity. Resilience is associated with personality traits such as optimism, creativity,
and intelligence, as well as belief of social support and connectedness to the environment
[16]. The current crisis offers opportunities to see who copes best with the current
situation, versus those who experience the greatest difficulties, including the determinants
of these differences. It is also good to mention the availability of specific treatments
that can reduce stress, such as mindfulness-based interventions. Several recent studies
have shown that mindfulness can reduce depression and anxiety, and even improve motor
symptoms [17]. These courses are usually given in groups of patients, but they may
also be offered through online platforms. Such web-based solutions can also provide
a means to reduce social isolation, which is yet another hidden consequence of this
ongoing pandemic. Children are told to avoid visits to their parents living with PD
whenever possible, and grandchildren are best kept away at all. Even social contacts
resulting from home-based nursing interventions are now reduced. Online solutions
are again essential to diminish this feeling of social isolation, and to provide comfort
and hope for people living with PD who are now grounded within their homes.
Another hidden but potentially highly disconcerting consequence of the pandemic is
a marked reduction in physical activities. Many people are now largely and sometimes
completely stuck at home, being unable to go out for a regular walk, let alone to
see their physiotherapist or attend a fitness class. Recent evidence has shown that
physical exercise may attenuate clinical symptom progression in PD [18, 19]. One recent
trial, the Park-in-Shape study, compared a home-based physical aerobic exercise intervention
(consisting of 30–45 min of stationary cycling on a home-trainer, three times per
week for 6 months) with an active control condition (consisting of 30–45 min of stretching,
three times per week for 6 months) [19]. A between-group longitudinal difference of
4.2 points on the motor scores of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS)
was found, which was both significant and clinically relevant. Another study has shown
similar effects, also emphasizing the importance of dose: more intense exercise was
associated with better outcomes than moderately intense exercise [18]. It is unclear
which mechanisms explain these clinical effects, and in particular whether aerobic
exercise can potentially slow down disease progression of PD, or whether it is merely
a symptomatic effect via stimulation of compensatory cerebral changes that balance
nigrostriatal cell loss. Nevertheless, a loss of aerobic exercise during the COVID-19
pandemic may well lead to a worsening of motor symptoms in PD. Nonmotor issues such
as insomnia or constipation may also worsen due to lack of physical activity. Furthermore,
reduced physical exercise may contribute to increased psychological stress, thereby
further aggravating the symptoms of PD, as outlined above. Promoting home-based and
adequately dosed exercises, such as cycling on a stationary bicycle, is therefore
more important than ever before. In this regard, a hopeful consequence of the current
crisis has been the emergence of web-based exercise initiatives, such as online singing,
exercise or dancing classes for PD patients (for examples, see [20]). Such interventions
are not entirely new, but the current crisis has certainly accelerated their adoption
by large groups of patients, paradoxically making the access to these important interventions
more accessible than ever before, particularly for those living in loosely populated
areas of the world.
Taken together, it is clear that the COVID-19 pandemic will have major consequences
on our society and our way of life, and this definitely includes people living with
PD. Individuals with PD are at increased risk of experiencing the negative sequelae
of increased stress and reduced physical exercise, both “hidden sorrows” that can
worsen their motor as well as non-motor symptoms. However, there are also emerging
opportunities. This crisis calls for the rapid introduction of better self-management
strategies that can help patients to better deal with the challenges of social distancing
and the other consequences of this crisis. We believe that self-management strategies
that reduce stress (e.g., mindfulness), increase coping (e.g., cognitive behavioral
therapy) or increase physical exercise (e.g., home-based training programs, alone
or in groups) will play an increasing role in the treatment of PD. The implementation
of these interventions will have to be accelerated during this crisis, and we are
beginning to see persuasive examples of this in many countries, often initiated or
supported by large patient associations. Furthermore, this crisis also offers opportunities
for research. The COVID-19 pandemic is an external stressor that is aligned in time
for large groups of people. This provides a unique opportunity for researchers to
test how the pandemic influences the course of PD in existing longitudinal cohorts,
e.g., by taking advantage of wearable sensors or biological biomarkers. It also allows
researchers to test which factors protect patients from the detrimental consequences
of this crisis, increasing our insight in resilience in PD. As such, deleterious as
the current crisis may be, it will hopefully also bring some long-term positive outcomes
for the many people living with PD worldwide.
CONFLICT OF INTEREST
The authors have no conflict of interest to report.