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      Ocimum basilicum essential oil combined with deltamethrin to improve the management of Spodoptera frugiperda Translated title: Óleo essencial de Ocimum basilicum associado à deltametrina no manejo de Spodoptera frugiperda

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          Abstract

          ABSTRACT For an important and expensive crop such as corn, the resistance of Spodoptera frugiperda J.E. Smith to various pesticides has led to research throughout the world for a potential insecticide from a natural source. For the management of pest resistance, natural compounds associated with synthetic insecticides can be a promising tool because they can reduce the application of the synthetics molecules while maintaining their effectiveness and promoting the control of the pests. Linalool is a potential insecticide that is easily obtained because it is found in high concentrations in the essential oil of Ocimum basilicum L. Therefore, the present study aimed to evaluate the toxicity of this essential oil and its combination with deltamethrin to control S. frugiperda. Through dose response assays, the acute toxicities (LD50) of the essential oil and deltamethrin were estimated. Additionally, the combination of these materials was also assessed, attaining a reduction of 80% of the LD50 of deltamethrin while obtaining the same result as when the pyrethroid was administered alone. From these results, it is expected that the combination of natural compounds and synthetic insecticides will be a promising practice, helping to manage resistance while reducing the environmental impact of toxic compounds.

          Translated abstract

          RESUMO Para uma cultura importante e expressiva como o milho, a resistência de Spodoptera frugiperda J.E. Smith a vários inseticidas atraiu a atenção no mundo para pesquisar o potencial inseticida de compostos naturais. Para o manejo da resistência, os compostos naturais associados a inseticidas sintéticos podem ser uma ferramenta promissória por reduzirem a aplicação das moléculas sintéticas para que não percam sua eficácia, além de promover o controle das pragas. O linalol é um terpenoide considerado como inseticida potencial, pode ser facilmente obtido naturalmente uma vez que é encontrado em alta concentração no óleo essencial de Ocimum basilicum. Portanto, o presente estudo teve como objetivo avaliar a toxicidade deste óleo essencial e sua combinação com deltametrina no controle de Spodoptera frugiperda. Através do ensaio de dose-resposta, foi estimada a toxicidade aguda (DL50) do óleo essencial e da deltametrina. Adicionalmente, foi também avaliada a combinação entre ambos, alcançando uma redução de 80% da DL50 de deltametrina para se obter o mesmo resultado quando o piretroide foi administrado sozinho. A partir dos nossos resultados, espera-se que uma combinação de uso de compostos naturais e inseticidas sintéticos possa ser uma prática promissora, auxiliando no manejo da resistência de pragas e principalmente reduzindo os impactos ambientais de compostos tóxicos.

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          Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis.

          Physiological anti-inflammatory mechanisms can potentially be exploited for the treatment of inflammatory disorders. Here we report that the neurotransmitter acetylcholine inhibits HMGB1 release from human macrophages by signaling through a nicotinic acetylcholine receptor. Nicotine, a selective cholinergic agonist, is more efficient than acetylcholine and inhibits HMGB1 release induced by either endotoxin or tumor necrosis factor-alpha (TNF-alpha). Nicotinic stimulation prevents activation of the NF-kappaB pathway and inhibits HMGB1 secretion through a specific 'nicotinic anti-inflammatory pathway' that requires the alpha7 nicotinic acetylcholine receptor (alpha7nAChR). In vivo, treatment with nicotine attenuates serum HMGB1 levels and improves survival in experimental models of sepsis, even when treatment is started after the onset of the disease. These results reveal acetylcholine as the first known physiological inhibitor of HMGB1 release from human macrophages and suggest that selective nicotinic agonists for the alpha7nAChR might have therapeutic potential for the treatment of sepsis.
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            Bioassay Analysis usingR

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              Identification of essential oil components by gas chromatography/mass spectroscopy.

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                cagro
                Ciência e Agrotecnologia
                Ciênc. agrotec.
                Editora da Universidade Federal de Lavras (Lavras, MG, Brazil )
                1413-7054
                1981-1829
                December 2017
                : 41
                : 6
                : 665-675
                Affiliations
                [3] Uberlândia Minas Gerais orgnameUniversidade Federal de Uberlândia orgdiv1Instituto de Química Brazil
                [1] Uberlândia Minas Gerais orgnameUniversidade Federal de Uberlândia orgdiv1Instituto de Ciências Agrárias Brazil
                [2] Lavras Minas Gerais orgnameUniversidade Federal de Lavras orgdiv1Departamento de Entomologia/DEN Brazil
                Article
                S1413-70542017000600665
                10.1590/1413-70542017416016317
                4f8ebfd7-3bab-4e35-9dc9-180ff445d096

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 24 April 2017
                : 24 July 2017
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 45, Pages: 11
                Product

                SciELO Brazil


                sinergismo.,Natural insecticides,linalool,fall armyworm,pyrethroid,synergism.,Inseticidas naturais,linalol,lagarta-do-cartucho,piretroides

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