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      Critical disease related to SARS-CoV-2 infection in children from the Amazon region: an observational study

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          Abstract

          This is a multicentre prospective cohort including critically ill children and adolescents, with confirmed critical disease related to SARS-CoV-2, admitted to three tertiary paediatric intensive care units in the Brazilian Amazon, between April 2020 and July 2022. 208 patients were included (median age was 3.5 years). The majority had malnutrition (62%) and comorbidities (60.6%). Mechanical ventilation support, cardiogenic shock and acute respiratory distress syndrome occurred in 47%, 30% and 34.1% of patients, respectively. There were 37 (18%) deaths. A poor outcome of severe COVID-19 and multisystem inflammatory syndrome in children was observed in children and adolescents from the Brazilian Amazon.

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          Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis

          Boyan K. Tsankov, Joannie M. Allaire, Michael Irvine … (2020)
          Highlights What is known • Adults with comorbidities are more likely to suffer from severe manifestations of COVID-19 • Children with COVID-19 have less severe disease manifestations than adults • Children may experience multisystem inflammatory syndrome due to COVID-19 What is new • Children with comorbidities may be at an increased risk for PICU admission and/or severe COVID-19 • Children with comorbidities may be at an increased risk of mortality during COVID-19 infection • Childhood obesity likely contributes to more serious manifestations of COVID-19
          Article 0 comments Cited 152 times – based on 0 reviews     Review now
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            Hospitalizations of Children and Adolescents with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, July 2021–January 2022

            Kristin J Marks, Michael Whitaker, Onika Anglin … (2022)
            Article 0 comments Cited 79 times – based on 0 reviews     Review now
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              Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry

              Utpal Bhalala, Katja Gist, Sandeep Tripathi … (2021)
              Supplemental Digital Content is available in the text.
              Article 0 comments Cited 17 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): BMJ Paediatr Open
                Journal ID (iso-abbrev): BMJ Paediatr Open
                Journal ID (hwp): bmjpo
                Journal ID (publisher-id): bmjpo
                Title: BMJ Paediatrics Open
                Publisher: BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                ISSN (Electronic): 2399-9772
                Publication date Collection: 2023
                Publication date (Electronic): 25 April 2023
                Publication date PMC-release: 25 April 2023
                Volume: 7
                Issue: 1
                Electronic Location Identifier: e001865
                Affiliations
                [1 ]departmentPediatrics Department , Ringgold_385536Fundação Santa Casa de Misericórdia do Pará , Belem, Pará, Brazil
                [2 ]departmentPediatrics Department , Hospital Pronto-Socorro Municipal Mário Pinotti , Belem, Pará, Brazil
                [3 ]departmentPediatrics Department , Fundação Hospital de Clínicas Gaspar Vianna , Belem, Pará, Brazil
                [4 ]departmentPediatrics Rheumatology Department , Unifesp EPM , São Paulo, São Paulo, Brazil
                Author notes
                [Correspondence to ] Dr Emmerson Carlos Franco de Farias; emmersonfariasbrandynew@ 123456gmail.com
                Author information
                http://orcid.org/0000-0001-8627-5694
                Article
                Publisher ID: bmjpo-2023-001865
                DOI: 10.1136/bmjpo-2023-001865
                PMC ID: 10151234
                SO-VID: 4c969432-d58d-477b-8462-c1263935a3e4
                Copyright © © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
                License:

                This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:  http://creativecommons.org/licenses/by-nc/4.0/.

                History
                Date received : 12 January 2023
                Date accepted : 19 March 2023
                Categories
                Subject: Original Research Letter
                Subject: 1506
                Subject: 2474
                Custom metadata
                special-feature unlocked

                Keywords: covid-19,epidemiology,virology
                Data availability:
                Keywords: covid-19, epidemiology, virology

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