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      Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis

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          Abstract

          Orthogeriatrics is increasingly recommended in the care of hip fracture patients, although evidence for this model is conflicting or at least limited. Furthermore, there is no conclusive evidence on which model [geriatric medicine consultant service (GCS), geriatric medical ward with orthopedic surgeon consultant service (GW), integrated care model (ICM)] is superior. The review summarizes the effect of orthogeriatric care for hip fracture patients on length of stay (LOS), time to surgery (TTS), in-hospital mortality, 1-year mortality, 30-day readmission rate, functional outcome, complication rate, and cost. Two independent reviewers retrieved randomized controlled trials, controlled observational studies, and pre/post analyses. Random-effects meta-analysis was performed. Thirty-seven studies were included, totaling 37.294 patients. Orthogeriatric care significantly reduced LOS [mean difference (MD) − 1.55 days, 95% confidence interval (CI) (− 2.53; − 0.57)], but heterogeneity warrants caution in interpreting this finding. Orthogeriatrics also resulted in a 28% lower risk of in-hospital mortality [95%CI (0.56; 0.92)], a 14% lower risk of 1-year mortality [95%CI (0.76; 0.97)], and a 19% lower risk of delirium [95%CI (0.71; 0.92)]. No significant effect was observed on TTS and 30-day readmission rate. No consistent effect was found on functional outcome. Numerically lower numbers of complications were observed in orthogeriatric care, yet some complications occurred more frequently in GW and ICM. Limited data suggest orthogeriatrics is cost-effective. There is moderate quality evidence that orthogeriatrics reduces LOS, in-hospital mortality, 1-year mortality, and delirium of hip fracture patients and may reduce complications and cost, while the effect on functional outcome is inconsistent. There is currently insufficient evidence to recommend one or the other type of orthogeriatric care model.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s00223-021-00913-5.

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          Most cited references66

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          The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials

          Flaws in the design, conduct, analysis, and reporting of randomised trials can cause the effect of an intervention to be underestimated or overestimated. The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurate
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            Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

            Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of the review; few reviews report whether a protocol exists. Detailed, well-described protocols can facilitate the understanding and appraisal of the review methods, as well as the detection of modifications to methods and selective reporting in completed reviews. We describe the development of a reporting guideline, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015). PRISMA-P consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review. Funders and those commissioning reviews might consider mandating the use of the checklist to facilitate the submission of relevant protocol information in funding applications. Similarly, peer reviewers and editors can use the guidance to gauge the completeness and transparency of a systematic review protocol submitted for publication in a journal or other medium.
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              Meta-analysis: excess mortality after hip fracture among older women and men.

              Although an increased risk for death after hip fracture is well established, whether this excess mortality persists over time is unclear. To determine the magnitude and duration of excess mortality after hip fracture in older men and women. Electronic search of MEDLINE and EMBASE for English and non-English articles from 1957 to May 2009 and manual search of article references. Prospective cohort studies were selected by 2 independent reviewers. The studies had to assess mortality in women (22 cohorts) or men (17 cohorts) aged 50 years or older with hip fracture, carry out a life-table analysis, and display the survival curves of the hip fracture group and age- and sex-matched control groups. Survival curve data and items relevant to study validity and generalizability were independently extracted by 2 reviewers. Time-to-event meta-analyses showed that the relative hazard for all-cause mortality in the first 3 months after hip fracture was 5.75 (95% CI, 4.94 to 6.67) in women and 7.95 (CI, 6.13 to 10.30) in men. Relative hazards decreased substantially over time but did not return to rates seen in age- and sex-matched control groups. Through use of life-table methods, investigators estimated that white women having a hip fracture at age 80 years have excess annual mortality compared with white women of the same age without a fracture of 8%, 11%, 18%, and 22% at 1, 2, 5, and 10 years after injury, respectively. Men with a hip fracture at age 80 years have excess annual mortality of 18%, 22%, 26%, and 20% at 1, 2, 5, and 10 years after injury, respectively. Cohort studies varied, sometimes markedly, in size, duration of observation, selection of control populations, ascertainment of death, and adjustment for comorbid conditions. Only published data that displayed findings with survival curves were examined. Publication bias was possible. Older adults have a 5- to 8-fold increased risk for all-cause mortality during the first 3 months after hip fracture. Excess annual mortality persists over time for both women and men, but at any given age, excess annual mortality after hip fracture is higher in men than in women. Fund for Scientific Research and Willy Gepts Foundation, Universitair Ziekenhuis Brussel.
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                Author and article information

                Contributors
                evelien.gielen@uzleuven.be
                Journal
                Calcif Tissue Int
                Calcif Tissue Int
                Calcified Tissue International
                Springer US (New York )
                0171-967X
                1432-0827
                30 September 2021
                30 September 2021
                2022
                : 110
                : 2
                : 162-184
                Affiliations
                [1 ]GRID grid.5596.f, ISNI 0000 0001 0668 7884, Faculty of Medicine, , KU Leuven, ; Leuven, Belgium
                [2 ]GRID grid.7942.8, ISNI 0000 0001 2294 713X, Institute of Statistics, Biostatistics and Actuarial Sciences, , UCLouvain, ; Louvain-la-Neuve, Belgium
                [3 ]GRID grid.5596.f, ISNI 0000 0001 0668 7884, Gerontology and Geriatrics, Department of Public Health and Primary Care, , KU Leuven, ; Leuven, Belgium
                [4 ]GRID grid.410569.f, ISNI 0000 0004 0626 3338, Centre for Metabolic Bone Diseases, , UZ Leuven, ; Leuven, Belgium
                [5 ]GRID grid.410569.f, ISNI 0000 0004 0626 3338, Department of Geriatrics, , University Hospitals Leuven, ; Herestraat 49, 3000 Leuven, Belgium
                [6 ]GRID grid.414579.a, ISNI 0000 0004 0608 8744, Geriatrics Department, , Imelda Hospital, ; Bonheiden, Belgium
                Author information
                http://orcid.org/0000-0003-1821-5168
                http://orcid.org/0000-0001-5336-2791
                http://orcid.org/0000-0002-7289-1397
                http://orcid.org/0000-0001-9681-8330
                http://orcid.org/0000-0002-8985-1201
                Article
                913
                10.1007/s00223-021-00913-5
                8784368
                34591127
                4a382601-0af2-409a-9421-6f965bf87a44
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 14 June 2021
                : 6 September 2021
                Categories
                Original Research
                Custom metadata
                © Springer Science+Business Media, LLC, part of Springer Nature 2022

                Human biology
                geriatric co-management,hip fracture,meta-analysis,orthogeriatrics,osteoporosis,systematic review

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