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      Impact of rapid near-patient STI testing on service delivery outcomes in an integrated sexual health service in the United Kingdom: a controlled interrupted time series study

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          Abstract

          Objectives

          To evaluate the impact of a new clinic-based rapid sexually transmitted infection testing, diagnosis and treatment service on healthcare delivery and resource needs in an integrated sexual health service.

          Design

          Controlled interrupted time series study.

          Setting

          Two integrated sexual health services (SHS) in UK: Unity Sexual Health in Bristol, UK (intervention site) and Croydon Sexual Health in London (control site).

          Participants

          Electronic patient records for all 58 418 attendances during the period 1 year before and 1 year after the intervention.

          Intervention

          Introduction of an in-clinic rapid testing system for gonorrhoea and chlamydia in combination with revised treatment pathways.

          Outcome measures

          Time-to-test notification, staff capacity, cost per episode of care and overall service costs. We also assessed rates of gonorrhoea culture swabs, follow-up attendances and examinations.

          Results

          Time-to-notification and the rate of gonorrhoea swabs significantly decreased following implementation of the new system. There was no evidence of change in follow-up visits or examination rates for patients seen in clinic related to the new system. Staff capacity in clinics appeared to be maintained across the study period. Overall, the number of episodes per week was unchanged in the intervention site, and the mean cost per episode decreased by 7.5% (95% CI 5.7% to 9.3%).

          Conclusions

          The clear improvement in time-to-notification, while maintaining activity at a lower overall cost, suggests that the implementation of clinic-based testing had the intended impact, which bolsters the case for more widespread rollout in sexual health services.

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          Most cited references27

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          The use of controls in interrupted time series studies of public health interventions

          Interrupted time series analysis differs from most other intervention study designs in that it involves a before-after comparison within a single population, rather than a comparison with a control group. This has the advantage that selection bias and confounding due to between-group differences are limited. However, the basic interrupted time series design cannot exclude confounding due to co-interventions or other events occurring around the time of the intervention. One approach to minimizse potential confounding from such simultaneous events is to add a control series so that there is both a before-after comparison and an intervention-control group comparison. A range of different types of controls can be used with interrupted time series designs, each of which has associated strengths and limitations. Researchers undertaking controlled interrupted time series studies should carefully consider a priori what confounding events may exist and whether different controls can exclude these or if they could introduce new sources of bias to the study. A prudent approach to the design, analysis and interpretation of controlled interrupted time series studies is required to ensure that valid information on the effectiveness of health interventions can be ascertained.
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            The natural history of Chlamydia trachomatis infection in women: a multi-parameter evidence synthesis.

            The evidence base supporting the National Chlamydia Screening Programme, initiated in 2003, has been questioned repeatedly, with little consensus on modelling assumptions, parameter values or evidence sources to be used in cost-effectiveness analyses. The purpose of this project was to assemble all available evidence on the prevalence and incidence of Chlamydia trachomatis (CT) in the UK and its sequelae, pelvic inflammatory disease (PID), ectopic pregnancy (EP) and tubal factor infertility (TFI) to review the evidence base in its entirety, assess its consistency and, if possible, arrive at a coherent set of estimates consistent with all the evidence.
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              Conceptualising natural and quasi experiments in public health

              Background Natural or quasi experiments are appealing for public health research because they enable the evaluation of events or interventions that are difficult or impossible to manipulate experimentally, such as many policy and health system reforms. However, there remains ambiguity in the literature about their definition and how they differ from randomized controlled experiments and from other observational designs. We conceptualise natural experiments in the context of public health evaluations and align the study design to the Target Trial Framework. Methods A literature search was conducted, and key methodological papers were used to develop this work. Peer-reviewed papers were supplemented by grey literature. Results Natural experiment studies (NES) combine features of experiments and non-experiments. They differ from planned experiments, such as randomized controlled trials, in that exposure allocation is not controlled by researchers. They differ from other observational designs in that they evaluate the impact of events or process that leads to differences in exposure. As a result they are, in theory, less susceptible to bias than other observational study designs. Importantly, causal inference relies heavily on the assumption that exposure allocation can be considered ‘as-if randomized’. The target trial framework provides a systematic basis for evaluating this assumption and the other design elements that underpin the causal claims that can be made from NES. Conclusions NES should be considered a type of study design rather than a set of tools for analyses of non-randomized interventions. Alignment of NES to the Target Trial framework will clarify the strength of evidence underpinning claims about the effectiveness of public health interventions. Supplementary Information The online version contains supplementary material available at 10.1186/s12874-021-01224-x.
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                Author and article information

                Journal
                BMJ Open
                BMJ Open
                bmjopen
                bmjopen
                BMJ Open
                BMJ Publishing Group (BMA House, Tavistock Square, London, WC1H 9JR )
                2044-6055
                2023
                11 January 2023
                : 13
                : 1
                : e064664
                Affiliations
                [1 ]departmentNational Institute for Health and Care Research, Applied Research Collaboration West (NIHR ARC West) , University Hospitals Bristol and Weston NHS Foundation Trust , Bristol, UK
                [2 ]departmentPopulation Health Sciences , Bristol Medical School, University of Bristol , Bristol, UK
                [3 ]departmentUnity Sexual Health , University Hospitals Bristol and Weston NHS Foundation Trust , Bristol, UK
                [4 ]departmentBristol Haematology and Oncology Centre , University Hospitals Bristol and Weston NHS Foundation Trust , Bristol, UK
                [5 ]departmentCroydon Sexual Health , Croydon University Hospital , Croydon, UK
                [6 ]departmentSouthwest Regional Laboratory , UK Health Security Agency, North Bristol NHS Trust , Bristol, UK
                [7 ]departmentNational Institute for Health and Care Research, Health Protection Research Unit in Behavioural Science and Evaluation (NIHR HPRU) , University of Bristol , Bristol, UK
                Author notes
                [Correspondence to ] Dr Scott R Walter; scott.walter@ 123456bristol.ac.uk

                PJH and FDV are joint first authors.

                Author information
                http://orcid.org/0000-0002-1898-6301
                http://orcid.org/0000-0002-7914-8037
                Article
                bmjopen-2022-064664
                10.1136/bmjopen-2022-064664
                9835959
                36631238
                493f2340-79e4-4262-90ae-2d155a7bb959
                © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.

                This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

                History
                : 17 May 2022
                : 13 December 2022
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100000272, National Institute for Health Research;
                Award ID: NIHR200181
                Categories
                Sexual Health
                1506
                1733
                Original research
                Custom metadata
                unlocked

                Medicine
                sexual medicine,epidemiology,health economics
                Medicine
                sexual medicine, epidemiology, health economics

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