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      Anti-TNF Therapy in Pregnant Women With Inflammatory Bowel Disease: Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes.

      1 , 2 , 3 , 1 , 4 , 5 , 6 , 5 , 7 , 3 , 3 , 3 , 8 , 9 , 1 , 2 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 13 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 1 , 26 , 3 , 20
      Inflammatory bowel diseases
      Oxford University Press (OUP)
      anti–tumor necrosis factor alpha, counseling, inflammatory bowel disease, pregnancy, pregnancy outcome

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          Abstract

          Active inflammatory bowel disease (IBD) adversely affects pregnancy outcomes. Little is known about the risk of relapse after stopping anti-tumor necrosis factor (anti-TNF) treatment during pregnancy. We assessed the risk of relapse before delivery in women who discontinued anti-TNF treatment before gestational week (GW) 30, predictors of reduced infant birth weight, a marker associated with long-term adverse outcomes, and rates and satisfaction with counseling.

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          Author and article information

          Journal
          Inflamm Bowel Dis
          Inflammatory bowel diseases
          Oxford University Press (OUP)
          1536-4844
          1078-0998
          January 01 2020
          : 26
          : 1
          Affiliations
          [1 ] Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
          [2 ] Department of Medicine, Horsens Hospital, Horsens, Denmark.
          [3 ] Department of Gastroenterology, St Vincent's Hospital, and University of Melbourne, Melbourne, Australia.
          [4 ] Department of Medicine, Christchurch Hospital, University of Otago, Christchurch, New Zealand.
          [5 ] Department of Gastroenterology, Alfred Hospital, and Monash University, Melbourne, VIC, Australia.
          [6 ] Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.
          [7 ] Department of Biostatistics, University of Aarhus, Aarhus, Denmark.
          [8 ] School of Medicine and Pharmacology, University of Western Australia, Harry Perkins Institute for Medical Research, Murdoch, WA, Australia.
          [9 ] Centre for inflammatory Bowel Diseases, Saint John of God Hospital, Subiaco, WA, Australia.
          [10 ] Department of Medicine, Herning Hospital, Herning, Denmark.
          [11 ] Gastrounit, Medical Division, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
          [12 ] Department of Gastroenterology, Hospital of Southwest Jutland, Esbjerg, Denmark.
          [13 ] Department of Gastroenterology, Odense University Hospital, Odense, Denmark.
          [14 ] Department of Gastroenterology, St. Vincent's Hospital, Sydney, NSW, Australia.
          [15 ] Gastrounit, Medical Division, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
          [16 ] Department of Gastroenterology, Flinders Medical Centre, Bedford Park, SA, Australia.
          [17 ] Inflammatory Bowel Diseases Unit, Royal Brisbane & Women's Hospital, University of Queensland School of Medicine, Brisbane, QLD, Australia.
          [18 ] Department of Gastroenterology & Hepatology, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia.
          [19 ] Gastroenterology and Hepatology Unit, The Canberra Hospital, Australian National University, Canberra, ACT, Australia.
          [20 ] Department of Gastroenterology, Monash Health, and School of Clinical Sciences Monash University, Melbourne, VIC, Australia.
          [21 ] Abdominalcenter K, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
          [22 ] Department of Gastroenterology, Liverpool Hospital, Sydney, University of NSW, and Ingham Institute of Applied Medical Research, Sydney, Australia.
          [23 ] Medical Department, Zealand University Hospital, Køge, Denmark.
          [24 ] Department of Internal Medicine, Nykøbing Falster Hospital, Nykøbing, Denmark.
          [25 ] Mater Hospital, Department of Gastroenterology, Sydney, Australia.
          [26 ] Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
          Article
          5506434
          10.1093/ibd/izz110
          31141607
          48498c8a-ffc9-4002-8b90-6bfe65030555
          History

          pregnancy outcome,anti–tumor necrosis factor alpha,counseling,inflammatory bowel disease,pregnancy

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