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STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-κB/HIF-1α pathway
Qingqiu Chen ,
Li Tang ,
Yi Zhang ,
Chengyu Wan ,
Xiuxian Yu ,
Yuman Dong ,
Xiaoting Chen ,
Xueling Wang ,
Ning Li ,
Guang Xin ,
Meixia Zhang ,
Zhen Chen ,
Hai Niu ,
Wen Huang
March 2022
March 2022
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d6806192e206">Aging-related dysfunction of retinal pigment epithelium
(RPE) is the main pathogenic
factors for pathological angiogenesis due to dysregulated vascular endothelial growth
factor (VEGF) in retinal vascular diseases such as age-related macular degeneration
(AMD) and diabetic retinopathy (DR). However, the molecular mechanism behind the up-regulation
of VEGF in senescent RPE is still blurred.
</p>