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      Design of a consensus-based geriatric assessment tailored for older chronic kidney disease patients: results of a pragmatic approach

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          Key Summary points

          Aim

          To propose a consensus-based geriatric assessment for optimizing both routine care and research in older patients with advanced chronic kidney disease.

          Findings

          Using a pragmatic approach, we reached consensus on a suitable nephrology-tailored geriatric assessment to routinely identify major geriatric impairments in older patients with advanced chronic kidney disease. This geriatric assessment contains instruments in functional, cognitive, psychological, somatic, patient preferences, nutritional status, and social domains, and can be administered with patient questionnaires and professional-administered instruments by nurse (practitioners) in approximately 20 and 40 minutes, respectively.

          Message

          We propose a consensus test set for standardized nephrology-tailored geriatric assessment, which is currently being implemented in multiple hospitals and studies, to benefit clinical care for older patients with advanced chronic kidney disease and enhance research comparability.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s41999-021-00498-0.

          Abstract

          Purpose

          Unidentified cognitive decline and other geriatric impairments are prevalent in older patients with advanced chronic kidney disease (CKD). Despite guideline recommendation of geriatric evaluation, routine geriatric assessment is not common in these patients. While high burden of vascular disease and existing pre-dialysis care pathways mandate a tailored geriatric assessment, no consensus exists on which instruments are most suitable in this population to identify geriatric impairments. Therefore, the aim of this study was to propose a geriatric assessment, based on multidisciplinary consensus, to routinely identify major geriatric impairments in older people with advanced CKD.

          Methods

          A pragmatic approach was chosen, which included focus groups, literature review, inventory of current practices, an expert consensus meeting, and pilot testing. In preparation of the consensus meeting, we composed a project team and an expert panel (n = 33), drafted selection criteria for the selection of instruments, and assessed potential instruments for the geriatric assessment.

          Results

          Selection criteria related to general geriatric domains, clinical relevance, feasibility, and duration of the assessment. The consensus-assessment contains instruments in functional, cognitive, psychological, somatic, patient preferences, nutritional status, and social domains. Administration of (seven) patient questionnaires and (ten) professional-administered instruments, by nurse (practitioners), takes estimated 20 and 40 min, respectively. Results are discussed in a multidisciplinary meeting including at least nephrology and geriatric expertise, informing nephrology treatment decisions, and follow-up interventions among which comprehensive geriatric assessment.

          Conclusion

          This first multidisciplinary consensus on nephrology-tailored geriatric assessment intent to benefit clinical care and enhance research comparability for older patients with advanced CKD.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s41999-021-00498-0.

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          Most cited references59

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          A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation

          The objective of this study was to develop a prospectively applicable method for classifying comorbid conditions which might alter the risk of mortality for use in longitudinal studies. A weighted index that takes into account the number and the seriousness of comorbid disease was developed in a cohort of 559 medical patients. The 1-yr mortality rates for the different scores were: "0", 12% (181); "1-2", 26% (225); "3-4", 52% (71); and "greater than or equal to 5", 85% (82). The index was tested for its ability to predict risk of death from comorbid disease in the second cohort of 685 patients during a 10-yr follow-up. The percent of patients who died of comorbid disease for the different scores were: "0", 8% (588); "1", 25% (54); "2", 48% (25); "greater than or equal to 3", 59% (18). With each increased level of the comorbidity index, there were stepwise increases in the cumulative mortality attributable to comorbid disease (log rank chi 2 = 165; p less than 0.0001). In this longer follow-up, age was also a predictor of mortality (p less than 0.001). The new index performed similarly to a previous system devised by Kaplan and Feinstein. The method of classifying comorbidity provides a simple, readily applicable and valid method of estimating risk of death from comorbid disease for use in longitudinal studies. Further work in larger populations is still required to refine the approach because the number of patients with any given condition in this study was relatively small.
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            The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.

            To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia. Validation study. A community clinic and an academic center. Ninety-four patients meeting MCI clinical criteria supported by psychometric measures, 93 patients with mild Alzheimer's disease (AD) (Mini-Mental State Examination (MMSE) score > or =17), and 90 healthy elderly controls (NC). The MoCA and MMSE were administered to all participants, and sensitivity and specificity of both measures were assessed for detection of MCI and mild AD. Using a cutoff score 26, the MMSE had a sensitivity of 18% to detect MCI, whereas the MoCA detected 90% of MCI subjects. In the mild AD group, the MMSE had a sensitivity of 78%, whereas the MoCA detected 100%. Specificity was excellent for both MMSE and MoCA (100% and 87%, respectively). MCI as an entity is evolving and somewhat controversial. The MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing in the normal range on the MMSE.
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              Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living

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                Author and article information

                Contributors
                c.g.n.voorend@lumc.nl
                Journal
                Eur Geriatr Med
                Eur Geriatr Med
                European Geriatric Medicine
                Springer International Publishing (Cham )
                1878-7649
                1878-7657
                19 April 2021
                19 April 2021
                2021
                : 12
                : 5
                : 931-942
                Affiliations
                [1 ]GRID grid.10419.3d, ISNI 0000000089452978, Department of Internal Medicine (Nephrology), , Leiden University Medical Center, ; Leiden, The Netherlands
                [2 ]GRID grid.412966.e, ISNI 0000 0004 0480 1382, Department of Internal Medicine, Division of General Internal Medicine, Section Geriatric Medicine, , Maastricht University Medical Center+, ; Maastricht, The Netherlands
                [3 ]GRID grid.4494.d, ISNI 0000 0000 9558 4598, Department of Nephrology, , University Medical Centre Groningen, University of Groningen, ; Groningen, The Netherlands
                [4 ]Department of Internal Medicine, St. Antonius hospital, Nieuwegein, The Netherlands
                [5 ]GRID grid.413591.b, ISNI 0000 0004 0568 6689, Department of Nephrology, , Haga Hospital, ; The Hague, The Netherlands
                [6 ]GRID grid.10419.3d, ISNI 0000000089452978, Department of Gerontology and Geriatrics, , Leiden University Medical Center, ; Leiden, The Netherlands
                Author information
                http://orcid.org/0000-0002-7097-6995
                http://orcid.org/0000-0003-1004-9994
                http://orcid.org/0000-0002-5062-2567
                http://orcid.org/0000-0002-1822-6863
                http://orcid.org/0000-0003-3106-3568
                Article
                498
                10.1007/s41999-021-00498-0
                8463384
                33871790
                468b6fec-0445-4fbc-a9c6-2497572fd4ef
                © The Author(s) 2021

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 18 January 2021
                : 8 April 2021
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100002997, Nierstichting;
                Award ID: A1D3P04
                Award Recipient :
                Categories
                Research Paper
                Custom metadata
                © European Geriatric Medicine Society 2021

                chronic kidney diseases,clinical decision-making,consensus development,frailty,aged,geriatric assessment

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