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Function and expression of the proton-coupled amino acid transporter PAT1 along the rat gastrointestinal tract: implications for intestinal absorption of gaboxadol.
M l Broberg
1 ,
R Holm ,
H Tønsberg ,
S Frølund ,
K B Ewon ,
A l Nielsen ,
B Brodin ,
A Jensen ,
M A Kall ,
K V Christensen ,
C U Nielsen
Oct 2012
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Abstract
Intestinal absorption via membrane transporters may determine the pharmacokinetics of drug compounds. The hypothesis is that oral absorption of gaboxadol (4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-ol) in rats occurs via the proton-coupled amino acid transporter, rPAT1 (encoded by the gene rSlc36a1). Consequently, we aimed to elucidate the in vivo role of rPAT1 in the absorption of gaboxadol from various intestinal segments obtained from Sprague-Dawley rats.