The human vestibular cortex: functional anatomy of OP2, its connectivity and the effect of vestibular disease

Abstract

Area OP2 in the posterior peri-sylvian cortex has been proposed to be the core human vestibular cortex. We investigated the functional anatomy of OP2 and adjacent areas (OP2 ⁺) using spatially constrained independent component analysis (ICA) of functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. Ten ICA-derived subregions were identified. OP2 ⁺ responses to vestibular and visual motion were analyzed in 17 controls and 17 right-sided vestibular neuritis patients who had previously undergone caloric and optokinetic stimulation during fMRI. In controls, a posterior part of right OP2 ⁺ showed: (i) direction-selective responses to visual motion and (ii) activation during caloric stimulation that correlated positively with perceived self-motion, and negatively with visual dependence and peak slow-phase nystagmus velocity. Patients showed abnormal OP2 ⁺ activity, with an absence of visual or caloric activation of the healthy ear and no correlations with vertigo or visual dependence—despite normal slow-phase nystagmus responses to caloric stimulation. Activity in a lateral part of right OP2 ⁺ correlated with chronic visually induced dizziness in patients. In summary, distinct functional subregions of right OP2 ⁺ show strong connectivity to other vestibular areas and a profile of caloric and visual responses, suggesting a central role for vestibular function in health and disease.