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      1307. The Mycoplasma Conundrum

      abstract
      , M.D
      Open Forum Infectious Diseases
      Oxford University Press

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          Abstract

          Background

          Lockdown for Covid 19 between March 15 - 30, 2020 lead to sudden closures of schools, public gatherings, all but essential businesses, and stay-at-home orders. Between then and the end of April 2020, literally all enveloped respiratory viruses declined to virtually undetectable levels, suggesting a successful interruption of transmission. Weekly percentage positivity rates for M. pneumoniae and all other respiratory viruses from BioFire Syndromic Trends for weeks ending 3/7/2020- 4/24/2020.

          Weekly percentage positive rates are shown, with the Rhinovirus/Enterovirus rate divided by 3 and the M. pneumoniae rate multiplied by 10 to fit on the same scale.

          Methods

          We used the percentage positivity rates from BioFire Syndromic Trends and from GenMark Diagnostics to examine the post lockdown response of M. pneumoniae versus other respiratory viruses on the Respiratory Virus Panel (RP 2.0)

          Results

          As has been reported (Nawrocki J., et al, OFID 2021) and as shown in Figure 1, there was a rapid drop in the positivity rate for all enveloped respiratory viruses by 85.6% from an average rate of 2.014% positive for the week ending 3/14/20 to 0.29% for the week ending 4/18/20, while the positivity rate for M. pneumoniae actually increased by 44% from 0.536 % to 0.772%. The increase in M. pneumoniae positivity rate from its baseline of 0.51 ± 0.38 between 1/25/20 - 3/21/20 vs 0.71 ± 0.09 between 3/28/20 - 4/25/20 was significantly higher by t test, p=0.00574. Data from GenMark was available only monthly but also showed an upward rise from march to April, 2020.

          Conclusion

          It is well documented that M. pneumoniae is transmitted through respiratory mechanisms, yet lockdown measures sufficient to dramatically reduce ordinary respiratory virus transmission had no comparable effect on transmission of Mycoplasma pneumoniae. It is also well known that M. pneumoniae persists in the respiratory tract as long as months after an infection. Therefore, it is possible that this reservoir continued to be a source of transmission for M. pneumoniae, even though lockdown measures effectively interrupted the enveloped respiratory viruses.

          Disclosures

          Kenneth Rand, M.D., BioFire Diagnostics (Advisor or Review Panel member, Research Grant or Support)

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          Author and article information

          Journal
          Open Forum Infect Dis
          Open Forum Infect Dis
          ofid
          Open Forum Infectious Diseases
          Oxford University Press (US )
          2328-8957
          November 2021
          04 December 2021
          04 December 2021
          : 8
          : Suppl 1 , IDWeek 2021 Abstracts
          : S741-S742
          Affiliations
          University of Florida , Gainesville, FL
          Article
          ofab466.1499
          10.1093/ofid/ofab466.1499
          8644213
          43f2fe91-a085-4912-9f78-2df3c0a95184
          © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

          History
          Page count
          Pages: 2
          Categories
          Poster Abstracts
          AcademicSubjects/MED00290

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