Well-differentiated abdominal liposarcoma: experience of a tertiary care center

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Abstract

Background

We presented abdominal liposarcoma cases diagnosed and managed in a tertiary care center and also conducted a literature review on main features of this tumor.

Methods

Chart reviews of eight cases were conducted, and clinical, surgical, histopathological, and follow-up data were recorded.

Results

Overall, complete surgical resection was performed with adjacent organ resection in 25% of cases, and radiotherapy was not administered. Recurrence was developed in only one case and died after 2 years and 3 months, and other cases are under follow-up without recurrence. Histopatological examinations revealed findings of well-differentiated liposarcoma.

Conclusions

According to our surgical experience, the surgical margin positivity may not be a determining factor for the survival of patients with well-differentiated liposarcoma, and in the absence of macroscopic invasion, adjacent organ resection may not be required. Radiotherapy may not be preferred when complete resection of abdominal mass was achieved.

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Most cited references 16

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Liposarcoma: Molecular Genetics and Therapeutics

Rachel Conyers, Sophie Young, David Thomas (2010)

Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as pathognomonic translocation events and common chromosomal amplification or loss, to more complex rearrangements involving multiple chromosomes. The different subtypes of liposarcoma are spread across this spectrum and constitute an interesting tumour type for molecular review. This paper will outline molecular pathogenesis of the three main subtypes of liposarcoma: well-differentiated/dedifferentiated, myxoid/round cell, and pleomorphic liposarcoma. Both the molecular basis and future avenues for therapeutic intervention will be discussed.

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Childhood cancer.

Sladjana Novaković, C. J. S. Young, Michael R. Miller (1995)

Cancers of individual organs generally are composed of various histologic types, each with its own frequency and demographic patterns. For childhood cancers in particular, a classification of cancers by histologic type is important for understanding the etiology and progression of the disease. Data from the Surveillance, Epidemiology, and End Results (SEER) Program on 9308 microscopically confirmed malignant neoplasms in children younger than age 15, newly diagnosed during 1973-1987, were made available for analysis. Tumors were grouped histologically according to a classification previously utilized in an international volume of childhood cancer incidence. The most frequent histologic types were acute lymphocytic leukemia (23.6%), astrocytoma (9.6%), neuroblastoma (6.6%), and Wilms' tumor (6.4%). Acute lymphocytic leukemia accounted for 75% of childhood leukemia. The most common form of Hodgkin's disease was the nodular sclerosing subtype, which was diagnosed in 56% of all cases. Burkitt's and Burkitt-like disease accounted for approximately one third of non-Hodgkin's lymphoma, the sex ratio (male to female) being unusually high (5.7). Among the brain tumors, glioma was of interest because 198 cases (excluded from this analysis) were diagnosed without histologic confirmation--due, no doubt, to their inaccessibility for biopsy because they were located in the brain stem. The most common histologic type of soft tissue sarcoma was rhabdomyosarcoma, which accounted for 51% of the total, more than half of which were of the embryonal type. To the authors' knowledge, this report offers for the first time the relative frequencies of rare types of leukemias, such as megakaryoblastic leukemia, in childhood. This report also includes the frequencies of 21 rarer forms of soft tissue sarcoma. Five forms of childhood cancer had a 5-year relative survival rate of 85% or better. Of the cancers with the poorest outcome, three had relative survival rates of 46.5-49%; the relative survival rate of acute myelogenous leukemia was only 26.4%. The trends in survival over time for 21 types of childhood cancer also are included in this report. Further refinements in classification now are available through laboratory techniques utilizing molecular biology, immunology, and cytogenetics, which are of importance in etiologic studies, diagnosis, treatment, and prognosis. It would be important in the future for cancer registries to record the results of relevant laboratory tests for further analysis by subtype.

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Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas.

Frédérique Keslair, Florence Pedeutour, Agnès Leroux … (2009)

The MDM2 and HMGA2 genes are consistently amplified in well-differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS) whereas CDK4 is frequently but not always amplified in these tumors. Our goal was to determine whether the absence of CDK4 amplification was (a) correlated to a specific clinico-histopathologic profile; and (b) compensated by another genomic anomaly involving the CCND1/CDK4/P16INK4a/RB1/E2F pathway. We compared the clinical characteristics of a series of 143 WDLPS/DDLPS with amplification of both MDM2 and CDK4 (MDM2+/CDK4+) to a series of 45 WDLPS/DDLPS with MDM2 amplification and no CDK4 amplification (MDM2+/CDK4-). We used fluorescence in situ hybridization, real time quantitative reverse transcription PCR, and immunohistochemistry to explore the status of CCND1, P16INK4a, P14ARF, and RB1. We found that MDM2+/CDK4- WDLPS/DDLPS represent a distinct clinical subgroup with favorable prognostic features, including low-grade lipoma-like histology, peripheral location, and lower rate of recurrence. By using fluorescence in situ hybridization, we found that genomic aberrations expected to be alternative mechanisms for compensating the lack of CDK4 amplification, such as RB1 and CDKN2A deletions or CCND1 amplification, were very uncommon. In contrast, by using real time quantitative reverse transcription PCR and immunohistochemistry, we observed that overexpression of P16INK4a (and P14ARF) and CCND1 and reduced expression of RB1 were very frequent, independently of the CDK4 status. Our results underscore the complex coordinated regulation of the RB and p53 growth-control pathways in WDLPS/DDLPS. Because the absence of CDK4 amplification is not specifically counterbalanced by a genomic alteration of the CCND1/CDK4/P16INK4a/RB1/E2F pathway, CDK4 amplification may only represent a "MDM2-HMGA2-helper" in WDLPS/DDLPS tumorigenesis.

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Author and article information

Contributors

Kursat Karadayi: karadayi@cumhuriyet.edu.tr

Caglar Yildiz: dr_caglaryildiz@yahoo.com

Savas Karakus: karakussavas@yahoo.com

Atilla Kurt: akurt@cumhuriyet.edu.tr

Birkan Bozkurt: birkan.bozkurt@gmail.com

Sinan Soylu: ssoylu@cumhuriyet.edu.tr

Ayse A Cicekli: acicekli@cumhuriyet.edu.tr

Reyhan Egilmez: regilmez@cumhuriyet.edu.tr

Ali Cetin: dralicetin@yahoo.com

Journal

Journal ID (nlm-ta): World J Surg Oncol

Journal ID (iso-abbrev): World J Surg Oncol

Title: World Journal of Surgical Oncology

Publisher: BioMed Central (London )

ISSN (Electronic): 1477-7819

Publication date (Electronic): 1 May 2015

Publication date PMC-release: 1 May 2015

Publication date Collection: 2015

Volume: 13

Electronic Location Identifier: 166

Affiliations

[ ]Department of Surgery, Faculty of Medicine, Cumhuriyet University, Sivas, 58140 Turkey

[ ]Department of Obstetrics and Gynecology, Faculty of Medicine, Cumhuriyet University, Sivas, 58140 Turkey

[ ]Department of Pathology, Faculty of Medicine, Cumhuriyet University, Sivas, 58140 Turkey

[ ]The Division of Surgical Oncology, Faculty of Medicine, Cumhuriyet University, Sivas, 58140 Turkey

Article

Publisher ID: 580

DOI: 10.1186/s12957-015-0580-z

PMC ID: 4422134

PubMed ID: 25927975

SO-VID: 4230bfae-5222-4aab-8290-080910b74775

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 16 September 2014

Date accepted : 8 April 2015

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ScienceOpen disciplines: Surgery

Keywords: liposarcoma,abdomen,surgical management

Data availability:

ScienceOpen disciplines: Surgery

Keywords: liposarcoma, abdomen, surgical management

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Well-differentiated abdominal liposarcoma: experience of a tertiary care center

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Abstract

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Most cited references 16

Liposarcoma: Molecular Genetics and Therapeutics

Childhood cancer.

Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas.

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Cited by 8

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