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      Identification of Diseases in Newborns Using Advanced Acoustic Features of Cry Signals

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          Abstract

          Our challenge in the current study is to extend research on the cries of newborns for the early diagnosis of different pathologies. This paper proposes a recognition system for healthy and pathological cries using a probabilistic neural network classifier. Two different kinds of features have been used to characterize newborn cry signals: 1) acoustic features such as fundamental frequency glide (F 0glide) and resonance frequencies dysregulation (RFs dys); 2) conventional features such as mel-frequency cestrum coefficients.

          This paper describes the automatic estimation of the proposed characteristics and the performance evaluation of these features in identifying pathological cries. The adopted methods for F 0glides and RFs dys estimation are based on the derived function of the F0 contour and the jump “J” of the RFs between two subsequent tunings, respectively. The database used contains 3250 cry samples of full-term and preterm newborns, and includes healthy and pathologic cries.

          The obtained results indicate the important association between the quantified features and some studied pathologies, and also an improvement in the identification of pathologic cries. The best result obtained is 88.71% for the correct identification of health status of preterm newborns, and 82% for the correct identification of full-term infants with a specific disease. We conclude that using the proposed characteristics improves the diagnosis of pathologies in newborns. Moreover, the method applied in the estimation of these characteristics allows us to extend this study to other uninvestigated pathologies.

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          Most cited references38

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          Assessment of infant cry: acoustic cry analysis and parental perception.

          Infant crying signals distress to potential caretakers who can alleviate the aversive conditions that gave rise to the cry. The cry signal results from coordination among several brain regions that control respiration and vocal cord vibration from which the cry sounds are produced. Previous work has shown a relationship between acoustic characteristics of the cry and diagnoses related to neurological damage, SIDS, prematurity, medical conditions, and substance exposure during pregnancy. Thus, assessment of infant cry provides a window into the neurological and medical status of the infant. Assessment of infant cry is brief and noninvasive and requires recording equipment and a standardized stimulus to elicit a pain cry. The typical protocol involves 30 seconds of crying from a single application of the stimulus. The recorded cry is submitted to an automated computer analysis system that digitizes the cry and either presents a digital spectrogram of the cry or calculates measures of cry characteristics. The most common interpretation of cry measures is based on deviations from typical cry characteristics. Another approach evaluates the pattern across cry characteristics suggesting arousal or under-arousal or difficult temperament. Infants with abnormal cries should be referred for a full neurological evaluation. The second function of crying--to elicit caretaking--involves parent perception of the infant's needs. Typically, parents are sensitive to deviations in cry characteristics, but their perception can be altered by factors in themselves (e.g., depression) or in the context (e.g., culture). The potential for cry assessment is largely untapped. Infant crying and parental response is the first language of the new dyadic relationship. Deviations in the signal and/or misunderstanding the message can compromise infant care, parental effectiveness, and undermine the budding relationship. (c) 2005 Wiley-Liss, Inc. MRDD Research Reviews 2005;11:83-93.
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            The SIFT algorithm for fundamental frequency estimation

            J. Markel (1972)
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              Nonlinear source-filter coupling in phonation: vocal exercises.

              Nonlinear source-filter coupling has been demonstrated in computer simulations, in excised larynx experiments, and in physical models, but not in a consistent and unequivocal way in natural human phonations. Eighteen subjects (nine adult males and nine adult females) performed three vocal exercises that represented a combination of various fundamental frequency and formant glides. The goal of this study was to pinpoint the proportion of source instabilities that are due to nonlinear source-tract coupling. It was hypothesized that vocal fold vibration is maximally destabilized when F(0) crosses F(1), where the acoustic load changes dramatically. A companion paper provides the theoretical underpinnings. Expected manifestations of a source-filter interaction were sudden frequency jumps, subharmonic generation, or chaotic vocal fold vibrations that coincide with F(0)-F(1) crossovers. Results indicated that the bifurcations occur more often in phonations with F(0)-F(1) crossovers, suggesting that nonlinear source-filter coupling is partly responsible for source instabilities. Furthermore it was observed that male subjects show more bifurcations in phonations with F(0)-F(1) crossovers, presumably because in normal speech they are less likely to encounter these crossovers as much as females and hence have less practice in suppressing unwanted instabilities.
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                Author and article information

                Journal
                Biomed Signal Process Control
                Biomed Signal Process Control
                BSPC
                Biomedical Signal Processing and Control
                Elsevier Ltd.
                1746-8094
                01 April 2019
                2019
                : 50
                : 35-44
                Affiliations
                [* ]Faculty of Science and Technology, Ziane Achour University, 3117 Djelfa, Algeria
                [** ]Department of Electrical Engineering, École de technologie supérieure, H3C 1K3 Montréal (Qc), Canada
                Author notes
                Corresponding Author: Yasmina Kheddache, e-mail: yasmina.kheddache.1@ 123456etsmtl.net fax: + (001) 514 396-8684
                Article
                BSPC-50-035
                10.1016/j.bspc.2019.01.010
                7672377
                41f84805-172f-4e4e-b23f-e4169f7eff10
                © 2019 The Author(s).

                This manuscript version is made available under the CC-BY-NC-ND 4.0 license.

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                pathologic cry,classification,probabilistic neural network,mel-frequency cestrum coefficients,rf dysregulations,f0 glides

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