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Stuck in Division or Passing through
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Abstract
Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis
(D-mitosis), a fact that has useful clinical ramifications. However, this delay is
seldom permanent, and in the presence of an active SAC most cells ultimately escape
mitosis and enter the next G1 as tetraploid cells. This review defines and discusses
the various factors that determine how long a cell remains in mitosis when it cannot
satisfy the SAC and also discusses the cell's subsequent fate.