Conversion therapy from N3 unresectable lung adenocarcinoma to radical surgery: a
      case report

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Abstract

Patients with N3 non-small cell lung cancer (NSCLC) have unresectable tumors. Although significant progress has been made in the past decades for such tumors, the average median survival time remains at 10 months. Equally dismal long-term survival rates were reported with the average 5-year-suvival rate at 9%. Here, we report on a case of a patient with locally advanced disease that was treated with conversion therapy using targeted anti-PD-1 immunotherapy with platinum-based chemotherapy. Following this therapeutic regimen, the tumor showed a reversion to pN0 from pN3 and the patient showed a progression free survival time of at least 33 months.

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Author and article information

Journal

Journal ID (nlm-ta): Ann Transl Med

Journal ID (iso-abbrev): Ann Transl Med

Journal ID (publisher-id): ATM

Title: Annals of Translational Medicine

Publisher: AME Publishing Company

ISSN (Print): 2305-5839

ISSN (Electronic): 2305-5847

Publication date (Print and electronic): October 2019

Publication date (Print): October 2019

Volume: 7

Issue: 20

Electronic Location Identifier: 590

Affiliations

[1 ]Department of Thoracic Surgery, Hunan Province Dikuang Hospital , Changsha 410007, China;

[2 ]Department of Surgery, School of Medicine, University of Occupational and Environmental Health , Kitakyushu, Japan;

[3 ]Department of General Thoracic Surgery, National Hospital Organization, Saitama Hospital , Wako, Japan;

[4 ]Department of Radiation Oncology (Maastro Clinic), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center , Maastricht, The Netherlands;

[5 ]Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University , Changsha 410000, China

Author notes

Correspondence to: Aihui Liao. Department of Thoracic Surgery, Hunan Province Dikuang Hospital, Changsha 410007, China. Email: yufenglei@ 123456csu.edu.cn .

Article

Accession ID: PMC6861792 Pmcid ID: PMC6861792 Pmc-uid ID: 6861792 Publisher ID: atm-07-20-590

DOI: 10.21037/atm.2019.09.113

PMC ID: 6861792

PubMed ID: 31807571

SO-VID: 407e4d72-aa05-4187-a4ce-b5b98b2ef4f2

History

Date received : 18 September 2019

Date accepted : 23 September 2019

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Conversion therapy from N3 unresectable lung adenocarcinoma to radical surgery: a case report

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