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      The impact of the SARS‐CoV‐2 pandemic on the management of chronic limb‐threatening ischemia and wound care

      research-article
      , DPM, MS, FACFAS, FAAWC 1 , , , MS, CRNP, CWCN‐AP, FAAWC 2 , , MPhil 3 , , MD 4 , 5 , , APRN, MSN, FNP‐C 6 , , MD 7 , , DPM 8 , , MD FSCAI 9 , , MD FACS 10 , 11 , , MD, ABWMS, CWS‐P, UHM 12 , , DPM, MBA, MSc, CWSP, FFPM RCPS (Glasgow) 13 , , MD, FASE, FSCAI, FACC 14 , , PhD, MA 3
      Wound Repair and Regeneration
      John Wiley & Sons, Inc.
      chronic limb‐threatening ischemia, COVID‐19, SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2, wound care

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          Abstract

          In the wake of the coronavirus pandemic, the critical limb ischemia (CLI) Global Society aims to develop improved clinical guidance that will inform better care standards to reduce tissue loss and amputations during and following the new SARS‐CoV‐2 era. This will include developing standards of practice, improve gaps in care, and design improved research protocols to study new chronic limb‐threatening ischemia treatment and diagnostic options. Following a round table discussion that identified hypotheses and suppositions the wound care community had during the SARS‐CoV‐2 pandemic, the CLI Global Society undertook a critical review of literature using PubMed to confirm or rebut these hypotheses, identify knowledge gaps, and analyse the findings in terms of what in wound care has changed due to the pandemic and what wound care providers need to do differently as a result of these changes. Evidence was graded using the Oxford Centre for Evidence‐Based Medicine scheme. The majority of hypotheses and related suppositions were confirmed, but there is noticeable heterogeneity, so the experiences reported herein are not universal for wound care providers and centres. Moreover, the effects of the dynamic pandemic vary over time in geographic areas. Wound care will unlikely return to prepandemic practices. Importantly, Levels 2–5 evidence reveals a paradigm shift in wound care towards a hybrid telemedicine and home healthcare model to keep patients at home to minimize the number of in‐person visits at clinics and hospitalizations, with the exception of severe cases such as chronic limb‐threatening ischemia. The use of telemedicine and home care will likely continue and improve in the postpandemic era.

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          Most cited references111

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          COVID-19 transforms health care through telemedicine: evidence from the field

          Abstract This study provides data on the feasibility and impact of video-enabled telemedicine use among patients and providers and its impact on urgent and non-urgent health care delivery from one large health system (NYU Langone Health) at the epicenter of the COVID-19 outbreak in the United States. Between March 2nd and April 14th 2020, telemedicine visits increased from 369.1 daily to 866.8 daily (135% increase) in urgent care after the system-wide expansion of virtual health visits in response to COVID-19, and from 94.7 daily to 4209.3 (4345% increase) in non-urgent care post expansion. Of all virtual visits post expansion, 56.2% and 17.6% urgent and non-urgent visits, respectively, were COVID-19-related. Telemedicine usage was highest by patients aged 20-44, particularly for urgent care. The COVID-19 pandemic has driven rapid expansion of telemedicine use for urgent care and non-urgent care visits beyond baseline periods. This reflects an important change in telemedicine that other institutions facing the COVID-19 pandemic should anticipate.
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            Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II).

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              Antibody evasion by the P.1 strain of SARS-CoV-2

              Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates. However, new strains have emerged with multiple mutations: P.1 from Brazil, B.1.351 from South Africa and B.1.1.7 from the UK (12, 10 and 9 changes in the spike respectively). All have mutations in the ACE2 binding site with P.1 and B.1.351 having a virtually identical triplet: E484K, K417N/T and N501Y, which we show confer similar increased affinity for ACE2. We show that, surprisingly, P.1 is significantly less resistant to naturally acquired or vaccine induced antibody responses than B.1.351 suggesting that changes outside the RBD impact neutralisation. Monoclonal antibody 222 neutralises all three variants despite interacting with two of the ACE2 binding site mutations, we explain this through structural analysis and use the 222 light chain to largely restore neutralization potency to a major class of public antibodies.
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                Author and article information

                Contributors
                drvdriver@aol.com
                Journal
                Wound Repair Regen
                Wound Repair Regen
                10.1111/(ISSN)1524-475X
                WRR
                Wound Repair and Regeneration
                John Wiley & Sons, Inc. (Hoboken, USA )
                1067-1927
                1524-475X
                29 October 2021
                29 October 2021
                : 10.1111/wrr.12975
                Affiliations
                [ 1 ] Wound Healing, Limb Preservation and Hyperbaric Centers Inova Heart and Vascular Institute Inova Health System Falls Church Virginia USA
                [ 2 ] Wound Care Services George Washington University Hospital Washington District of Columbia USA
                [ 3 ] Strategic Solutions, Inc. Bozeman Montana USA
                [ 4 ] Center for Wound Healing South Shore Health Weymouth Massachusetts USA
                [ 5 ] Boston University School of Medicine Boston Massachusetts USA
                [ 6 ] PULSE Amputation Prevention Centers Affiliates, El Paso Cardiology Associates, P.A. El Paso Texas USA
                [ 7 ] Mount Sinai West Hospital Icahn School of Medicine New York New York USA
                [ 8 ] West Boca Center for Wound Healing Coconut Creek Florida USA
                [ 9 ] Palm Beach Heart & Vascular JFK Wound Management & Limb Preservation Center Lake Worth Florida USA
                [ 10 ] Inova Heart and Vascular Institute Falls Church Virginia USA
                [ 11 ] Department of Surgery Inova Health System Falls Church Virginia USA
                [ 12 ] Saratoga Hospital Center for Wound Healing and Hyperbaric Medicine Saratoga Springs New York USA
                [ 13 ] Barry University School of Podiatric Medicine Miami Shores Florida USA
                [ 14 ] Advanced Cardiac & Vascular Centers for Amputation Prevention Grand Rapids Michigan USA
                Author notes
                [*] [* ] Correspondence

                Vickie R. Driver, 1788 North Pierce st Arlington Virginia 22209, USA

                Email: drvdriver@ 123456aol.com

                Author information
                https://orcid.org/0000-0002-5148-5365
                https://orcid.org/0000-0002-2265-6639
                Article
                WRR12975
                10.1111/wrr.12975
                8661621
                34713947
                403f1306-a152-4eb9-a7d7-ea19e482f5e7
                © 2021 The Authors. Wound Repair and Regeneration published by Wiley Periodicals LLC on behalf of The Wound Healing Society.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 13 September 2021
                : 28 June 2021
                : 05 October 2021
                Page count
                Figures: 1, Tables: 1, Pages: 17, Words: 15592
                Funding
                Funded by: The Global CLI Society
                Categories
                Perspective Article
                Perspective Article
                Custom metadata
                2.0
                corrected-proof
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.9 mode:remove_FC converted:10.12.2021

                Emergency medicine & Trauma
                chronic limb‐threatening ischemia,covid‐19,sars‐cov‐2,severe acute respiratory syndrome coronavirus 2,wound care

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