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      Central Adjudication Identified Additional and Prognostically Important Myocardial Infarctions in Patients Undergoing Percutaneous Coronary Intervention.

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          Abstract

          In the CHAMPION PHOENIX trial, cangrelor reduced the primary composite end point of death, myocardial infarction (MI), ischemia-driven revascularization, or stent thrombosis at 48 hours. This study aimed to explore the impact of event adjudication and the prognostic importance of MI reported by a clinical events committee (CEC) or site investigators (SIs).

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          Author and article information

          Journal
          Circ Cardiovasc Interv
          Circulation. Cardiovascular interventions
          Ovid Technologies (Wolters Kluwer Health)
          1941-7632
          1941-7640
          July 2019
          : 12
          : 7
          Affiliations
          [1 ] Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, CA (C.B.O., K.W.M.).
          [2 ] Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Germany (C.B.O.).
          [3 ] Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, MA (D.L.B.).
          [4 ] University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy (S.L.).
          [5 ] Columbia University Medical Center and the Cardiovascular Research Foundation, New York City, NY (G.W.S.).
          [6 ] Beth Israel Deaconess Medical Center, Division of Cardiology, Boston, MA (C.M.G.).
          [7 ] FACT (French Alliance for Cardiovascular Clinical Trials), DHU FIRE, INSERM Unité 1148, Université Paris-Diderot, and Hôpital Bichat, Assistance-Publique-Hôpitaux de Paris, Paris, France, and NHLI, Imperial College, Royal Brompton Hospital, London, United Kingdom (P.G.S.).
          [8 ] Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany (C.W.H.).
          [9 ] Duke University Medical Center, Durham, NC (M.D.W., S.M., R.D.L.).
          [10 ] Scripps Clinic and Scripps Translational Science Institute, La Jolla, CA (M.J.P.).
          [11 ] Elysis Llc, Carlisle, MA (J.P.).
          [12 ] Green Lane Cardiovascular Service, Auckland, New Zealand (H.D.W.).
          [13 ] Department of Medicine, Stanford University School of Medicine, Stanford, CA (R.A.H.).
          Article
          10.1161/CIRCINTERVENTIONS.118.007342
          31296081
          3c5a4cff-80ac-4d6b-8d45-2de878d7201e
          History

          biomarker,clopidogrel,myocardial infarction,percutaneous coronary intervention,thrombosis

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