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PEEP Titration Is Markedly Affected by Trunk Inclination in Mechanically Ventilated Patients with COVID-19 ARDS: A Physiologic, Cross-Over Study.
Francesco Marrazzo
1 ,
Stefano Spina
1 ,
Francesco Zadek
2 ,
Clarissa Forlini
1 ,
Gabriele Bassi
1 ,
Riccardo Giudici
1 ,
Giacomo Bellani
2
,
3 ,
Roberto Fumagalli
1
,
2 ,
Thomas Langer
1
,
2
Jun 08 2023
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Abstract
Changing trunk inclination affects lung function in patients with ARDS. However, its impacts on PEEP titration remain unknown. The primary aim of this study was to assess, in mechanically ventilated patients with COVID-19 ARDS, the effects of trunk inclination on PEEP titration. The secondary aim was to compare respiratory mechanics and gas exchange in the semi-recumbent (40° head-of-the-bed) and supine-flat (0°) positions following PEEP titration.