Combined Use of Immunoreactivities of RIG-I with Efp/TRIM25 for Predicting Prognosis of Patients With Estrogen Receptor-positive Breast Cancer.

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Abstract

We previously identified estrogen-responsive finger protein (Efp) as an estrogen-induced gene, and showed that the positive immunoreactivity of Efp is a poor prognostic factor for patients with breast cancer. We also demonstrated that Efp has distinctive roles in innate immunity by activating pattern recognition receptor retinoic acid-inducible gene I (RIG-I). The clinical value of RIG-I protein expression in breast cancer had not been evaluated in relationship with patients' prognosis.

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Journal ID (iso-abbrev): Clin Breast Cancer

Title: Clinical breast cancer

Publisher: Elsevier BV

ISSN (Electronic): 1938-0666

ISSN (Print): 1526-8209

Publication date (Electronic): October 2021

Volume: 21

Issue: 5

Affiliations

[1 ] Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Department of Pathology, Toranomon Hospital, Tokyo, Japan.

[2 ] Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

[3 ] Department of Pathology, Toranomon Hospital, Tokyo, Japan.

[4 ] Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan.

[5 ] Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan; Department of Breast and Endocrine Surgery, Toranomon Hospital, Tokyo, Japan.

[6 ] Department of Breast and Endocrine Surgery, Toranomon Hospital, Tokyo, Japan.

[7 ] Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

[8 ] Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan; Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan. Electronic address: sinoue@tmig.or.jp.

Article

Publisher Item ID: S1526-8209(20)30328-1

DOI: 10.1016/j.clbc.2020.12.001

PubMed ID: 33386231

SO-VID: 36a30b37-a939-45eb-abcf-04af3b411e51

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Keywords: Estrogen-responsive finger protein,Immunoreactivity,Pattern recognition receptor,Prognostic factor,Retinoic acid-inducible gene I

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Keywords: Estrogen-responsive finger protein, Immunoreactivity, Pattern recognition receptor, Prognostic factor, Retinoic acid-inducible gene I

Combined Use of Immunoreactivities of RIG-I with Efp/TRIM25 for Predicting Prognosis of Patients With Estrogen Receptor-positive Breast Cancer.

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