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      Oral manifestations of systemic leukemia-first sign of presentation

      case-report

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          Abstract

          Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy that left untreated or undiagnosed can lead to death within few days. Hence, early diagnosis and appropriate treatment become necessary. Oral manifestations in AML could be the presenting feature or could a part of systemic manifestations. Gingival lesions appear as generalized enlargement with hemorrhagic discoloration with or without spontaneous bleeding. Sometimes, gingival lesions itself could a presenting sign without any other systemic manifesto. We report a similar case which was undiagnosed earlier and the patient came with a complaint of only the gingival swelling.

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          Most cited references7

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          Leukemic Oral Manifestations and their Management.

          Leukemia is the most common neoplastic disease of the white blood cells which is important as a pediatric malignancy. Oral manifestations occur frequently in leukemic patients and may present as initial evidence of the disease or its relapse. The symptoms include gingival enlargement and bleeding, oral ulceration, petechia, mucosal pallor, noma, trismus and oral infections. Oral lesions arise in both acute and chronic forms of all types of leukemia. These oral manifestations either may be the result of direct infiltration of leukemic cells (primary) or secondary to underlying thrombocytopenia, neutropenia, or impaired granulocyte function. Despite the fact that leukemia has long been known to be associated with oral lesions, the available literature on this topic consists mostly of case reports, without data summarizing the main oral changes for each type of leukemia. Therefore, the present review aimed at describing oral manifestations of all leukemia types and their dental management. This might be useful in early diagnosis, improving patient outcomes.
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            Acute leukaemia presenting as oral ulceration to a dental emergency service.

            Leukaemia is a neoplastic disease characterized by an excessive proliferation of immature white blood cells and their precursors. Oral lesions may be the presenting feature of acute leukaemias, which can be rapidly fatal if left untreated. This report describes the case of a 22-year-old female who presented to a dental emergency department with oral manifestations of acute leukaemia. It outlines the role of oral lesions in the diagnosis of acute leukaemias and emphasizes the importance of immediate referral by general dental practitioners.
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              Gingival hyperplasia complicating acute myelomonocytic leukemia.

              Many systemic illnesses manifest clinical signs in the oral cavity. A remarkable case of gingival hyperplasia heralding the presence of acute myelomonocytic leukemia (AML FAB-M4) is described. The oral manifestations of acute leukemia are reviewed.
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                Author and article information

                Journal
                J Indian Soc Periodontol
                J Indian Soc Periodontol
                JISP
                Journal of Indian Society of Periodontology
                Wolters Kluwer - Medknow (India )
                0972-124X
                0975-1580
                Jul-Aug 2021
                01 July 2021
                : 25
                : 4
                : 347-349
                Affiliations
                [1] Department of Oral Medicine and Radiology, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India
                [1 ] Department of Oral Medicine and Radiology, Rajendra Institute of Medical Sciences, Medical Institute of Ranchi University, Ranchi, Jharkhand, India
                [2 ] Department of Oral Medicine and Radiology, Bhabha Dental College, Bhopal, Madhya Pradesh, India
                Author notes

                The work belongs to the Department of Oral Medicine and Radiology, People's College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India

                Address for correspondence: Dr. Annette Milton Bhambal, Department of Oral Medicine and Radiology, College of People's Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India. E-mail: 11drann@ 123456gmail.com
                Article
                JISP-25-347
                10.4103/jisp.jisp_551_20
                8336771
                34393407
                350c1491-f18f-414d-a946-de48760b3b69
                Copyright: © 2021 Indian Society of Periodontology

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                : 26 July 2020
                : 26 January 2021
                : 09 February 2021
                Categories
                Case Report

                Dentistry
                acute myeloid leukemia,bleeding,chloroma,gingival overgrowth,hematologic neoplasm,oral manifestations

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