There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Recently, a three-state model is presented to describe the intracellular traffic of
unconventional (single-headed) kinesin KIF1A [Phys. Rev. Lett. {\bf 95}, 118101 (2005)],
in which each motor can bind strongly or weakly to its microtubule track, and each
binding site of the track might be empty or occupied by one motor. As the usual two-state
model, i.e. the totally asymmetric simple exclusion process (TASEP) with motor detachment
and attachment, in steady state of the system, this three-state model also exhibits
shock (or domain wall separating the high-density and low density phases) and boundary
layers. In this study, using mean-field analysis, the conditions of existence of shock
and boundary layers are obtained theoretically. Combined with numerical calculations,
the properties of shock are also studied. This study will be helpful to understand
the biophysical properties of the collective transport of kinesin KIF1A.