This study investigates the socio‐demographic factors and work from home challenges associated with job satisfaction and work performance. Using a cross‐sectional survey design and convenience sampling, data from 482 Indonesian employees were gathered via a web‐based questionnaire. Bivariate analysis was used to assess job satisfaction and work performance differences across several socio‐demographic factors. Hierarchical linear regression was performed to identify the contribution of socio‐demographic factors and work from home challenges on job satisfaction and work performance. All work from home challenges, with the exception of social isolation, linked significantly to job satisfaction and work performance. However, no significant differences in job satisfaction and work performance were found across most socio‐demographic factors. Our final model suggests that, after controlling socio‐demographic and work from home challenges, the length of employment and job satisfaction were the most significant determinants of work performance. This study provides insights for organizations wishing to raise employees’ satisfaction, and maximize the benefits gained by addressing work from home challenges, by improving some of the less favorable work from home practices of the past.