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      Natural killer cells: walking three paths down memory lane.

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          Abstract

          Immunological memory has traditionally been regarded as a unique feature of the adaptive immune response, mediated in an antigen-specific manner by T and B lymphocytes. All other hematopoietic cells, including natural killer (NK) cells, are classified as innate immune cells, which have been considered short-lived but can respond rapidly against pathogens in a manner not thought to be driven by antigen. Interestingly, NK cells have recently been shown to survive long term after antigen exposure and subsequently mediate antigen-specific recall responses. In this review, we address the similarities between, and the controversies surrounding, three major viewpoints of NK memory that have arisen from these recent studies: (i) mouse cytomegalovirus (MCMV)-induced memory; (ii) cytokine-induced memory; and (iii) liver-restricted memory cells.

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          Author and article information

          Journal
          Trends Immunol
          Trends in immunology
          Elsevier BV
          1471-4981
          1471-4906
          Jun 2013
          : 34
          : 6
          Affiliations
          [1 ] Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
          Article
          NIHMS458992 S1471-4906(13)00031-8
          10.1016/j.it.2013.02.005
          3674190
          23499559
          301c1604-16a1-4b35-a483-e0145cdd64af
          Copyright © 2013 Elsevier Ltd. All rights reserved.
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