The deformation history of the Neoproterozoic Central African Orogenic Belt in southern Cameroon is well recorded in the low- to high-grade rocks outcropping in the area around Yaoundé. The fabrics in these rocks are consistent with two main ductile deformation events D 1 and D 2. D 1 predated emplacement of calc-alkaline dioritic bodies and caused the formation of nappes that resulted in high-pressure granulite metamorphism of soft sediments. A strong overprinting of these nappes during D 2 symmetric extension, probably associated with large-scale foliation boudinage and (or) gneissic doming and intense magmatic underplating, gave rise to regional flat-lying fabrics. The latter were further buckled by D 3 and D 4 folding phases defining a vertical constriction occurring with a major east–west to NW–SE shortening direction. The corresponding F 3 and F 4 folds trend north–south to NE–SW and east–west to NW–SE, respectively, and represent the main regional strain patterns. Based on the east–west to NW–SE maximum shortening orientation indicated by F 3 folds, it is proposed that the nappe-stacking phase D 1 occurred in the same direction. The deformation history in the area can thus be described as corresponding principally to alternating east–west to NW–SE contractions and north–south to NE–SW orogenic-parallel extensions. At the regional scale, this could be due to the Transaharan east–west collisional system.