Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

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Abstract

The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective of the nutraceuticals market, with a brief comparison with that in China, as an illustration of how individual health supplements increase and decrease in popularity in regional terms. Recent changes in sales patterns, mainly taken from the US market, are summarized and a selection of five newer products, which have not been subject to extensive recent review are profiled: astaxanthin, a carotenoid found in red algae, seafood, salmon and trout, as an antioxidant; cannabidiol, a non‐euphoric marijuana ingredient used as mood enhancer and for painful/inflammatory conditions; modified extracts of ginseng used in new indications including dementia and space travel; monk fruit, a non‐sugar high intensity sweetener and nigella seed, a popular food ingredient and Asian medicine, which has experienced an extraordinary rise in sales recently. This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Most cited references 109

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Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

Orrin Devinsky, J. Cross, Linda Laux … (2017)

New England Journal of Medicine, 376(21), 2011-2020

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Record: found
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Article: found

Is Open Access

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

Ranga Rao Ambati, Phang Siew Moi, Sarada Ravi … (2014)

There is currently much interest in biological active compounds derived from natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases. Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione) is a xanthophyll carotenoid, contained in Haematococcus pluvialis, Chlorella zofingiensis, Chlorococcum, and Phaffia rhodozyma. It accumulates up to 3.8% on the dry weight basis in H. pluvialis. Our recent published data on astaxanthin extraction, analysis, stability studies, and its biological activities results were added to this review paper. Based on our results and current literature, astaxanthin showed potential biological activity in in vitro and in vivo models. These studies emphasize the influence of astaxanthin and its beneficial effects on the metabolism in animals and humans. Bioavailability of astaxanthin in animals was enhanced after feeding Haematococcus biomass as a source of astaxanthin. Astaxanthin, used as a nutritional supplement, antioxidant and anticancer agent, prevents diabetes, cardiovascular diseases, and neurodegenerative disorders, and also stimulates immunization. Astaxanthin products are used for commercial applications in the dosage forms as tablets, capsules, syrups, oils, soft gels, creams, biomass and granulated powders. Astaxanthin patent applications are available in food, feed and nutraceutical applications. The current review provides up-to-date information on astaxanthin sources, extraction, analysis, stability, biological activities, health benefits and special attention paid to its commercial applications.

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Abstract: found
Article: found

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

Orrin Devinsky, Anup Patel, J. Cross … (2018)

Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy. We investigated the efficacy and safety of cannabidiol added to a regimen of conventional antiepileptic medication to treat drop seizures in patients with the Lennox-Gastaut syndrome, a severe developmental epileptic encephalopathy.

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Author and article information

Journal

Title: British Journal of Pharmacology

Abbreviated Title: Br J Pharmacol

Publisher: Wiley

ISSN (Print): 0007-1188

ISSN (Electronic): 1476-5381

Publication date Created: March 2020

Publication date (Electronic): February 06 2020

Publication date (Print): March 2020

Volume: 177

Issue: 6

Pages: 1227-1240

Affiliations

[1 ]School of Pharmacy University of Reading, Whiteknights Reading UK

[2 ]Research Centre for Pharmacology and Toxicology, Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

[3 ]Department of Pharmacy, School of Medicine and Surgery University of Naples Federico II Naples Italy