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      Comparison of the chemical health risk assessment of exposure to metal fumes for the furnace operator of a foundry industry using quantitative and semi-quantitative methods

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          Abstract

          Heavy metals have several adverse effects on the workers' bodies due to their accumulation in the vital organs. Besides that, the current study aimed to assess the health risk of exposure to metal fumes for furnace operators working in a foundry industry based on the three different methods. The current sectional descriptive-analytical research conducted on a foundry industry in Isfahan (Iran) in 2022. Three common methods currently available, including the Semi-Quantitative Risk Assessment Method (SQRCA) and two methods provided based on the US-EPA provided technique, were used in this study. At first, the extent of people's exposure to metal fumes of Fe, Ni, Cr, and Mn was measured. Then, the chemical risk assessment of exposure to these metals' fumes was done using the three methods, and their results were compared. The SPSS Ver.25 has been used for data analysis and comparison in the current study. Results indicated that the furnace operator's exposure to all four metals was above the allowed limit of occupational exposure. The chemical risk assessment results also showed that in the first method (US-EPA-based), the risk of exposure for all workers was acceptable, while in the second method (SQCRA), the risk level of a majority of workers was medium, and in the third method (US-EPA-based), the risk level of a majority of workers was not acceptable. Comparing the methods showed that average risk scores in the first and second methods were significant compared to the exposure to fumes with equivalent concentration (P value<0.05). The average score of carcinogenicity risk in method 3 was significant compared to the concentration of chromium and nickel (P- value < 0.05), but it was not significant for iron and manganese and the non-carcinogenic risk of chromium and nickel. Chemical exposure risk level for the furnace operator was approximately moderate in all three methods. In terms of complexity and information required to implement the method, all three methods were almost the same, with the difference that the results of the first method cannot be generalized to other people who have the same job conditions because individual information such as a person's weight is used to calculate its score.

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          Most cited references37

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          Toxicity, mechanism and health effects of some heavy metals

          Heavy metal toxicity has proven to be a major threat and there are several health risks associated with it. The toxic effects of these metals, even though they do not have any biological role, remain present in some or the other form harmful for the human body and its proper functioning. They sometimes act as a pseudo element of the body while at certain times they may even interfere with metabolic processes. Few metals, such as aluminium, can be removed through elimination activities, while some metals get accumulated in the body and food chain, exhibiting a chronic nature. Various public health measures have been undertaken to control, prevent and treat metal toxicity occurring at various levels, such as occupational exposure, accidents and environmental factors. Metal toxicity depends upon the absorbed dose, the route of exposure and duration of exposure, i.e. acute or chronic. This can lead to various disorders and can also result in excessive damage due to oxidative stress induced by free radical formation. This review gives details about some heavy metals and their toxicity mechanisms, along with their health effects.
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            Nickel, its adverse health effects & oxidative stress.

            Nickel-induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen species is reviewed. Nickel is a known haematotoxic, immunotoxic, neurotoxic, genotoxic, reproductive toxic, pulmonary toxic, nephrotoxic , hepatotoxic and carcinogenic agent. This article presents a selective review on nickel and effect of its acute, subchronic and chronic doses on certain metabolically active tissues in human as well as animals. Nickel exposure causes formation of free radicals in various tissues in both human and animals which lead to various modifications to DNA bases, enhanced lipid peroxidation, and altered calcium and sulphydryl homeostasis. The primary route for nickel toxicity is depletion of glutathione and bonding to sulphydryl groups of proteins. Nickel homeostasis, nickel-induced activation of signaling pathways and the protective role of enzymatic and non-enzymatic antioxidants against nickel toxicity and carcinogenicity are also discussed.
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              Contamination and health risk assessment of heavy metals in China’s lead–zinc mine tailings: A meta–analysis

              The lead-zinc areas of China have faced serious foulteousqulated heavy metal pollution. In this study, data on As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn concentrations in China's lead-zinc mine tailings were collected and screened from published literature (2015-2020). The contamination assessments, geographical distributions, and health risk assessments of the eight heavy metals were analyzed. The results revealed that the mean concentrations of As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn exceeded the corresponding background values for soils. Moreover, most of the lead-zinc mine tailing areas contaminated by heavy metals were located in the southern and eastern regions of China. The health risk assessment results indicated that oral ingestion was the main exposure route of heavy metals in the mine tailings, and children were more vulnerable to adverse effects. For a single metal, As and Pb presented high non-carcinogenic risks, and As and Cu presented the unacceptable carcinogenic risks. This study provides a timely analysis proving the urgent necessity of the treatment of heavy metal pollution in lead-zinc tailings in China.
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                Author and article information

                Contributors
                Journal
                Heliyon
                Heliyon
                Heliyon
                Elsevier
                2405-8440
                11 January 2023
                January 2023
                11 January 2023
                : 9
                : 1
                : e12913
                Affiliations
                [a ]Department of Occupational Health and Safety Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
                [b ]Student Research Committee, Department of Occupational Health and Safety Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
                [c ]Faculty of Health, Safety and Environmental Engineering, Najafabad Branch, Islamic Azad University, Iran
                Author notes
                []Corresponding author. Student Research Committee, Department of Occupational Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. rezaesmaeili794@ 123456yahoo.com
                Article
                S2405-8440(23)00120-2 e12913
                10.1016/j.heliyon.2023.e12913
                9860271
                2bf41a48-9214-43ed-b1ac-f02eb654931b
                © 2023 The Authors

                This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

                History
                : 26 October 2022
                : 16 December 2022
                : 9 January 2023
                Categories
                Research Article

                risk assessment,metal fume,foundry,sqcra,us-epa
                risk assessment, metal fume, foundry, sqcra, us-epa

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