细菌纤维素复合材料在骨组织工程领域的应用新进展 Translated title: New Advances in the Application of Bacterial Cellulose Composite Materials in the Field of Bone Tissue Engineering

Abstract

细菌纤维素是一种微生物生长过程中分泌的胞外高分子纳米材料，因其具有独特的三维纤维网状结构、良好的生物相容性、生物可降解性以及出色的机械性能而在骨组织工程领域备受关注。但细菌纤维素仍有不足，如低成骨活性、缺乏抗菌性能、孔径过小、降解速率和骨组织再生不匹配等问题，限制了其在骨组织工程领域的单独使用。因此，通过改性细菌纤维素并制备细菌纤维素复合材料成为近年来的研究热点。本综述总结了细菌纤维素的生产-改性-骨修复应用的相互关系，介绍了细菌纤维素的制备及其改性的方法，还详细阐述了细菌纤维素复合材料在骨组织工程领域的应用新进展，同时也指出了细菌纤维素复合材料目前面临的挑战与展望。

Translated abstract

Bacterial cellulose (BC) is a type of extracellular polymeric nanomaterial secreted by microorganisms over the course of their growth. It has gained significant attention in the field of bone tissue engineering due to its unique structure of three-dimensional fibrous network, excellent biocompatibility, biodegradability, and exceptional mechanical properties. Nevertheless, BC still has some weaknesses, including low osteogenic activity, a lack of antimicrobial properties, small pore size, issues with the degradation rate, and a mismatch in bone tissue regeneration, limiting its standalone use in the field of bone tissue engineering. Therefore, the modification of BC and the preparation of BC composite materials have become a recent research focus. Herein, we summarized the relationships between the production, modification, and bone repair applications of BC. We introduced the methods for the preparation and the modification of BC. Additionally, we elaborated on the new advances in the application of BC composite materials in the field of bone tissue engineering. We also highlighted the existing challenges and future prospects of BC composite materials.