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Prediction of HIV drug resistance based on virologic, immunologic, clinical, and/or adherence criteria in the Stratall ANRS 12110/ESTHER trial in Cameroon.
Charlotte Boullé
1 ,
Charles Kouanfack ,
Gabrièle Laborde-Balen ,
Avelin Fobang Aghokeng ,
Sylvie Boyer ,
Maria Patrizia Carrieri ,
Serge Kazé ,
Jean-Marc Mben ,
Marlise Dontsop ,
Bruno Spire ,
Martine Peeters ,
Eitel Mpoudi-Ngolé ,
Eric Delaporte ,
Christian Laurent
Aug 2013
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Abstract
Our study in Cameroonian rural district hospitals showed that the immunologic and clinical failure criteria had poor performance to identify human immunodeficiency virus drug resistance in a timely manner. Switching to second-line antiretroviral therapy after 2 consecutive viral loads ≥5000 copies/mL, as recommended by the World Health Organization, appeared to be the most appropriate strategy.