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      Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR.

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          Abstract

          We report occupational asthma and rhinitis in a formulation pharmacist, employed in the development of tafenoquine. Tafenoquine is a new anti-malarial drug in development; the pure drug substance has an asthma hazard index of zero and previously was not known to be a respiratory sensitizing agent. The implications of this finding for the refinement of quantitative structural analysis of asthmagenic chemicals are discussed.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Occup Med (Lond)
          Title: Occupational medicine (Oxford, England)
          Publisher: Oxford University Press (OUP)
          ISSN (Electronic): 1471-8405
          ISSN (Print): 0962-7480
          Publication date (Electronic): Apr 2015
          Volume: 65
          Issue: 3
          Affiliations
          [1 ] Department of Occupational and Environmental Medicine, Royal Brompton and Harefield NHS Trust and Imperial College, London, UK, j.cannon@rbht.nhs.uk.
          [2 ] Department of Occupational and Environmental Medicine, Royal Brompton and Harefield NHS Trust and Imperial College, London, UK.
          [3 ] Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK.
          [4 ] Department of Occupational Health, GlaxoSmithKline, Brentford, UK.
          Article
          Publisher Item ID: kqu193
          DOI: 10.1093/occmed/kqu193
          PubMed ID: 25663384
          SO-VID: 23dcb301-d5bd-4112-a5b5-15e05f516ca3
          History

          Keywords: respiratory sensitizer,Asthma hazard index,tafenoquine.
          Data availability:
          Keywords: respiratory sensitizer, Asthma hazard index, tafenoquine.

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