The role of ferroptosis in chronic intermittent hypoxia-induced liver injury in rats.

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Abstract

Obstructive sleep apnea (OSA) has been related to an increased risk of liver injury. Ferroptosis is a form of programmed cell death implicated in multiple physiological and pathological processes. This study aimed to explore the role of ferroptosis in chronic intermittent hypoxia (CIH)-induced liver injury as well as to uncover the underlying mechanisms using a CIH rat model.

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Journal

Journal ID (iso-abbrev): Sleep Breath

Title: Sleep & breathing = Schlaf & Atmung

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1522-1709

ISSN (Print): 1520-9512

Publication date (Electronic): Dec 2020

Volume: 24

Issue: 4

Affiliations

[1 ] Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, No 20, Chazhong road, Taijiang district, Fuzhou, Fujian Province, 350005, People's Republic of China.

[2 ] Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.

[3 ] College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, People's Republic of China.

[4 ] Department of Pathology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian Province, People's Republic of China.

[5 ] Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, No 20, Chazhong road, Taijiang district, Fuzhou, Fujian Province, 350005, People's Republic of China. chang4e@126.com.

[6 ] Fujian Provincial Sleep-Disordered Breathing Clinic Center, Fuzhou, Fujian Province, People's Republic of China. chang4e@126.com.

[7 ] Laboratory of Respiratory Disease of the Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China. chang4e@126.com.

Article

Publisher Item ID: 10.1007/s11325-020-02091-4

DOI: 10.1007/s11325-020-02091-4

PubMed ID: 32361960

SO-VID: 206cac4e-bcf2-4b12-b7ea-2736b2491311

History

Keywords: Obstructive sleep apnea,Liver injury,Ferroptosis,Chronic intermittent hypoxia

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Keywords: Obstructive sleep apnea, Liver injury, Ferroptosis, Chronic intermittent hypoxia

The role of ferroptosis in chronic intermittent hypoxia-induced liver injury in rats.

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Karger: Oncology

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