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Aggression in humans correlates with cerebrospinal fluid amine metabolites
October 1979
October 1979
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Abstract
<p class="first" id="d9047041e67">Cerebrospinal fluid of the major central metabolites
of serotonin (5HT), norepinephrine
(NE), and dopamine (DA)--5-hydroxyindoleacetic acid (5HIAA), 3-methoxy-4-hydroxy=phenylglycol
(MHPG), and homovanillic acid (HVA), respectively--were studied in a group of 26 age-similar
military men with no history of major psychiatric illness, but with various personality
disorders and difficulties adjusting to military life. Independently scored history
of aggressive behavior showed a significant negative correlation with 5HIAA (r = -0.78)
and a significant positive correlation with MHPG (r = 0.64).
</p>