Silent hypoxaemia in COVID‐19 patients

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

<p class="first" id="d3057249e302">The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in critical need of investigation. Some COVID-19 patients have been labelled with 'happy hypoxia', in which patient complaints of dyspnoea and observable signs of respiratory distress are reported to be absent. Based on ongoing debate, we highlight key respiratory and neurological components that could underlie variation in the presentation of silent hypoxaemia and define priorities for subsequent investigation. </p>

Related collections

Author and article information

Contributors

Tatum S. Simonson: (View ORCID Profile)

Tracy L. Baker: (View ORCID Profile)

Robert B. Banzett: (View ORCID Profile)

Tammie Bishop: (View ORCID Profile)

Jack L. Feldman: (View ORCID Profile)

Patrice G. Guyenet: (View ORCID Profile)

Emma J. Hodson: (View ORCID Profile)

Marc Poulin: (View ORCID Profile)

Jean M. Rawling: (View ORCID Profile)

Journal

Title: The Journal of Physiology

Abbreviated Title: J Physiol

Publisher: Wiley

ISSN (Print): 0022-3751

ISSN (Electronic): 1469-7793

Publication date Created: February 2021

Publication date (Electronic): January 04 2021

Publication date (Print): February 2021

Volume: 599

Issue: 4

Pages: 1057-1065

Affiliations

[1 ]Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine University of California San Diego CA USA

[2 ]Department of Comparative Biosciences University of Wisconsin – Madison WI USA

[3 ]Division of Pulmonary, Critical Care, & Sleep Medicine Beth Israel Deaconess Medical Center Department of Medicine Harvard Medical School Boston MA USA

[4 ]Target Discovery Institute University of Oxford Oxford UK

[5 ]Department of Population Health Sciences School of Medicine and Public Health University of Wisconsin – Madison WI USA

[6 ]Department of Neurobiology University of California Los Angeles CA USA

[7 ]Department of Pharmacology School of Medicine University of Virginia Charlottesville VA USA

[8 ]The Francis Crick Institute London UK

[9 ]The Department of Experimental Medicine and Immunotherapeutics University of Cambridge Cambridge UK

[10 ]Department of Physical Therapy Center for Respiratory Research and Rehabilitation College of Public Health and Health Professions University of Florida Gainesville FL USA

[11 ]Departments of Physiology & Pharmacology and Clinical Neurosciences Cumming School of Medicine and Faculty of Kinesiology University of Calgary Calgary Alberta Canada

[12 ]Departments of Family Medicine University of Calgary Calgary Alberta Canada

[13 ]Sleep Disorders Centre University of Manitoba Winnipeg Manitoba Canada

Article

DOI: 10.1113/JP280769

PMC ID: 7902403

PubMed ID: 33347610

SO-VID: 19d1ed6f-906e-4757-9864-f14fdf7d0ea1

License:

http://onlinelibrary.wiley.com/termsAndConditions#vor

http://doi.wiley.com/10.1002/tdm_license_1.1

History

Data availability:

Comments

Comment on this article

scite_

Cited by 36

See all cited by

- Version 1