One-Pot Synthesis of 3-Substituted 4H-Quinolizin-4-ones via Alkyne Substrate Control Strategy.

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Abstract

Three-substituted 4H-quinolizin-4-ones were obtained via a facile method with good selectivity and high efficiency. On the basis of alkyne substrate control, the mild and cost-efficient reaction has a broad substrate scope (20 examples, up to 93% yield) and is also easy to scale up. Active sites on the products allow for further modifications. The alkyne substrate control strategy could be further extended to achieve more complex three-substituted 4H-quinolizin-4-one skeletons.

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Journal

Journal ID (iso-abbrev): J Org Chem

Title: The Journal of organic chemistry

Publisher: American Chemical Society (ACS)

ISSN (Electronic): 1520-6904

ISSN (Print): 0022-3263

Publication date (Electronic): Feb 19 2021

Volume: 86

Issue: 4

Affiliations

[1 ] Department of Chemistry, Renmin University of China, Zhonggancun Street 59, Beijing 100872, P. R. China.

[2 ] College of Chemistry, Beijing Normal University, Xinjiekouwaidajie 19, Beijing 100875, P. R. China.

Article

DOI: 10.1021/acs.joc.0c02484

PubMed ID: 33372518

SO-VID: 16776dbd-5c5a-4414-b507-e8e7d3a52546

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