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      Urinary liver-type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone.

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          Abstract

          Urinary liver-type fatty acid binding protein (L-FABP) has potential utility as an early prognostic biomarker ahead of traditional severity scores in coronavirus disease 2019 and sepsis, however, the mechanism of elevated urinary L-FABP in the disease has not been clearly elucidated. We investigated the background mechanisms of urinary L-FABP excretion through non-clinical animal model focusing on histone, which is one of the aggravating factors in these infectious diseases.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Nephrology (Carlton)
          Title: Nephrology (Carlton, Vic.)
          Publisher: Wiley
          ISSN (Electronic): 1440-1797
          ISSN (Print): 1320-5358
          Publication date (Electronic): Jun 2023
          Volume: 28
          Issue: 6
          Affiliations
          [1 ] Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan.
          [2 ] Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.
          [3 ] Department of L-FABP Business, CMIC Holdings Co., Ltd, Tokyo, Japan.
          [4 ] Timewell Medical Co., Ltd, Tokyo, Japan.
          [5 ] Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture, Tokyo, Japan.
          [6 ] ARTham Therapeutics Inc, Kanagawa, Japan.
          [7 ] Department of Anatomy, St. Marianna University School of Medicine, Kanagawa, Japan.
          [8 ] Department of Medical Sports, Faculty of Health Care and Medical Sports, Teikyo Heisei University, Chiba, Japan.
          [9 ] National Center Biobank Network, National Center for Global Health and Medicine, Tokyo, Japan.
          Article
          DOI: 10.1111/nep.14162
          PubMed ID: 37076661
          SO-VID: 14a32a74-2851-4d89-8d4e-af71b103dd24
          History

          Keywords: acute kidney injury (AKI),urinary biomarker,liver-type fatty acid binding protein (L-FABP),histone
          Data availability:
          Keywords: acute kidney injury (AKI), urinary biomarker, liver-type fatty acid binding protein (L-FABP), histone

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