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      Value Set for the EQ-5D-Y-3L in Hungary

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          Abstract

          Background

          The Hungarian health technology assessment guidelines recommend the use of the EuroQol instrument family in quality-adjusted life-year calculations. However, no national value set exists for the EQ-5D-Y-3L or any other youth-specific instrument.

          Objective

          This study aims to develop a national value set of the EQ-5D-Y-3L for Hungary based on preferences of the general adult population.

          Methods

          This study followed the international valuation protocol for the EQ-5D-Y-3L. Two independent samples, representative of the Hungarian general adult population in terms of age and sex were recruited to complete online discrete choice experiment (DCE) tasks and composite time trade-off (cTTO) tasks by computer-assisted personal interviews. Adults valued hypothetical EQ-5D-Y-3L health states considering the health of a 10-year-old child. DCE data were modelled using a mixed logit model with random-correlated coefficients. Latent DCE utility estimates were mapped onto mean observed cTTO utilities using ordinary least squares regression.

          Results

          Overall, 996 and 200 respondents completed the DCE and cTTO surveys, respectively. For each domain, the value set resulted in larger utility decrements with more severe response levels. The relative importance of domains by level 3 coefficients was as follows: having pain or discomfort > feeling worried, sad or unhappy > mobility > doing usual activities > looking after myself. Overall, 12.3% of all health states had negative utilities in the value set, with the worst health state having the lowest predicted utility of − 0.485.

          Conclusion

          This study developed a national value set of the EQ-5D-Y-3L for Hungary. The value set enables to evaluate the cost utility of health technologies for children and adolescents based on societal preferences in Hungary.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s40273-022-01190-2.

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          Most cited references47

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          Mixed MNL models for discrete response

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            A program of methodological research to arrive at the new international EQ-5D-5L valuation protocol.

            To describe the research that has been undertaken by the EuroQol Group to improve current methods for health state valuation, to summarize the results of an extensive international pilot program, and to outline the key elements of the five-level EuroQol five-dimensional (EQ-5D-5L) questionnaire valuation protocol, which is the culmination of that work.
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              Development of the EQ-5D-Y: a child-friendly version of the EQ-5D

              Purpose To develop a self-report version of the EQ-5D for younger respondents, named the EQ-5D-Y (Youth); to test its comprehensibility for children and adolescents and to compare results obtained using the standard adult EQ-5D and the EQ-5D-Y. Methods An international task force revised the content of EQ-5D and wording to ensure relevance and clarity for young respondents. Children’s and adolescents’ understanding of the EQ-5D-Y was tested in cognitive interviews after the instrument was translated into German, Italian, Spanish and Swedish. Differences between the EQ-5D and the EQ-5D-Y regarding frequencies of reported problems were investigated in Germany, Spain and South Africa. Results The content of the EQ-5D dimensions proved to be appropriate for the measurement of HRQOL in young respondents. The wording of the questionnaire had to be adapted which led to small changes in the meaning of some items and answer options. The adapted EQ-5D-Y was satisfactorily understood by children and adolescents in different countries. It was better accepted and proved more feasible than the EQ-5D. The administration of the EQ-5D and of the EQ-5D-Y causes differences in frequencies of reported problems. Conclusions The newly developed EQ-5D-Y is a useful tool to measure HRQOL in young people in an age-appropriate manner.
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                Author and article information

                Contributors
                fanni.rencz@uni-corvinus.hu
                Journal
                Pharmacoeconomics
                Pharmacoeconomics
                Pharmacoeconomics
                Springer International Publishing (Cham )
                1170-7690
                1179-2027
                20 September 2022
                20 September 2022
                : 1-11
                Affiliations
                [1 ]GRID grid.17127.32, ISNI 0000 0000 9234 5858, Department of Health Policy, , Corvinus University of Budapest, ; 8 Fővám tér, 1093 Budapest, Hungary
                [2 ]GRID grid.17127.32, ISNI 0000 0000 9234 5858, Department of Statistics, , Corvinus University of Budapest, ; Budapest, Hungary
                [3 ]GRID grid.5591.8, ISNI 0000 0001 2294 6276, Doctoral School of Psychology, Institute of Psychology, , Eötvös Loránd University, ; Budapest, Hungary
                [4 ]GRID grid.11804.3c, ISNI 0000 0001 0942 9821, Károly Rácz Doctoral School of Clinical Medicine, , Semmelweis University, ; Budapest, Hungary
                [5 ]GRID grid.413458.f, ISNI 0000 0000 9330 9891, Health Services Management Department, , Guizhou Medical University, ; Guiyang, China
                [6 ]GRID grid.478988.2, ISNI 0000 0004 5906 3508, EuroQol Office, EuroQol Research Foundation, ; Rotterdam, The Netherlands
                Author information
                http://orcid.org/0000-0001-9674-620X
                http://orcid.org/0000-0002-6817-6454
                http://orcid.org/0000-0002-1450-4790
                http://orcid.org/0000-0001-5468-0847
                http://orcid.org/0000-0003-1438-321X
                http://orcid.org/0000-0002-6095-2295
                Article
                1190
                10.1007/s40273-022-01190-2
                9485017
                36123448
                11fae201-86ee-4d5f-bda8-693f743e940c
                © The Author(s) 2022

                Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 4 September 2022
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100005881, Emberi Eroforrások Minisztériuma;
                Award ID: TKP2020-IKA-02
                Funded by: FundRef http://dx.doi.org/10.13039/501100003825, Magyar Tudományos Akadémia;
                Award ID: János Bolyai Research Scholarship (BO/00304/21)
                Award Recipient :
                Funded by: Ministry for Innovation and Technology
                Award ID: New National Excellence Program
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/501100006419, EuroQol Research Foundation;
                Award ID: 192-2020VS
                Funded by: Corvinus University of Budapest
                Categories
                Original Research Article

                Economics of health & social care
                Economics of health & social care

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