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      Real-life experience with ceftolozane/tazobactam in Canada: results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry.

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          Abstract

          Ceftolozane/tazobactam is a cephalosporin/β-lactamase inhibitor combination with activity against Gram-negative bacilli. Here we report the use of ceftolozane/tazobactam in Canada using a national registry.

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          Author and article information

          Journal
          J Glob Antimicrob Resist
          Journal of global antimicrobial resistance
          Elsevier BV
          2213-7173
          2213-7165
          Jun 2021
          : 25
          Affiliations
          [1 ] Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: ggzhanel@pcsinternet.ca.
          [2 ] Department of Pharmacy, London Health Sciences Centre, London, Ontario, Canada.
          [3 ] Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
          [4 ] Department of Pharmacy, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
          [5 ] Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
          [6 ] Department of Pharmacy, Hamilton Health Sciences Centre, Hamilton, Ontario, Canada.
          [7 ] Department of Pharmacy, Ottawa Hospital, Ottawa, Ontario, Canada.
          [8 ] Section of Infectious Diseases, William Osler Health System, Brampton, Ontario, Canada.
          [9 ] Pharmacy Department, CIUSSS de l'Est-de-l'Île-de-Montréal, Montreal, Québec, Canada.
          [10 ] Section of Infectious Diseases, Department of Medicine, The Moncton Hospital, New Brunswick, Canada.
          [11 ] Department of Pharmacy, St Boniface Hospital, Winnipeg, Manitoba, Canada.
          [12 ] Department of Pharmacy, Sainte-Croix Hospital, Drummondville, Québec, Canada.
          [13 ] Infectious Diseases Clinic, Department of Health Sciences, University of Genoa and Policlinico San Marino IRCCS, Genoa, Italy.
          Article
          S2213-7165(21)00095-3
          10.1016/j.jgar.2021.03.025
          33984530
          0e2d9df6-4de9-4c62-b4fe-7f96291d3cba
          History

          Pneumonia,Adverse effect,Bacteraemia,CLEAR,Ceftolozane/tazobactam,Efficacy

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