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      COVID-19 outbreak and Urban dynamics: regional variations in India

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          Abstract

          India was the second highest COVID-19 affected country in the world with 2.1 million cases by 11th August. This study focused on the spatial transmission of the pandemic among the 640 districts in India over time, and aimed to understand the urban-centric nature of the infection. The connectivity context was emphasized that possibly had inflicted the outbreak. Using the modes of transmission data for the available cases, the diffusion of this disease was explained. Metropolitans contributed three-fourths of total cases from the beginning. The transport networks attributed significantly in transmitting the virus from the urban containment zones. Later, there was a gradual shift of infections from urban to rural areas; however, the numbers kept increasing in the former. The massive reverse migration after lockdown spiked the infected cases further. Districts with airports reported more with influx of international passengers. A profound east–west division in April with higher infections in the southern and western districts existed. By mid-May eastern India saw a steep rise in active cases. Moran’s I analysis showed a low autocorrelation initially which increased over time. Hotspot clustering was observed in western Maharashtra, eastern Tamil Nadu, Gujarat and around Kolkata by the second week of August. The diffusion was due to travel, exposure to infected individuals and among the frontline workers. Spatial regression models confirmed that urbanization was positively correlated with higher incidences of infections. Transit mediums, especially rail and aviation were positively associated. These models validated the crucial role of spatial proximity in diffusion of the pandemic.

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          Most cited references37

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          Global trends in emerging infectious diseases

          The next new disease Emerging infectious diseases are a major threat to health: AIDS, SARS, drug-resistant bacteria and Ebola virus are among the more recent examples. By identifying emerging disease 'hotspots', the thinking goes, it should be possible to spot health risks at an early stage and prepare containment strategies. An analysis of over 300 examples of disease emerging between 1940 and 2004 suggests that these hotspots can be accurately mapped based on socio-economic, environmental and ecological factors. The data show that the surveillance effort, and much current research spending, is concentrated in developed economies, yet the risk maps point to developing countries as the more likely source of new diseases. Supplementary information The online version of this article (doi:10.1038/nature06536) contains supplementary material, which is available to authorized users.
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            Early dynamics of transmission and control of COVID-19: a mathematical modelling study

            Summary Background An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to 95 333 confirmed cases as of March 5, 2020. Understanding the early transmission dynamics of the infection and evaluating the effectiveness of control measures is crucial for assessing the potential for sustained transmission to occur in new areas. Combining a mathematical model of severe SARS-CoV-2 transmission with four datasets from within and outside Wuhan, we estimated how transmission in Wuhan varied between December, 2019, and February, 2020. We used these estimates to assess the potential for sustained human-to-human transmission to occur in locations outside Wuhan if cases were introduced. Methods We combined a stochastic transmission model with data on cases of coronavirus disease 2019 (COVID-19) in Wuhan and international cases that originated in Wuhan to estimate how transmission had varied over time during January, 2020, and February, 2020. Based on these estimates, we then calculated the probability that newly introduced cases might generate outbreaks in other areas. To estimate the early dynamics of transmission in Wuhan, we fitted a stochastic transmission dynamic model to multiple publicly available datasets on cases in Wuhan and internationally exported cases from Wuhan. The four datasets we fitted to were: daily number of new internationally exported cases (or lack thereof), by date of onset, as of Jan 26, 2020; daily number of new cases in Wuhan with no market exposure, by date of onset, between Dec 1, 2019, and Jan 1, 2020; daily number of new cases in China, by date of onset, between Dec 29, 2019, and Jan 23, 2020; and proportion of infected passengers on evacuation flights between Jan 29, 2020, and Feb 4, 2020. We used an additional two datasets for comparison with model outputs: daily number of new exported cases from Wuhan (or lack thereof) in countries with high connectivity to Wuhan (ie, top 20 most at-risk countries), by date of confirmation, as of Feb 10, 2020; and data on new confirmed cases reported in Wuhan between Jan 16, 2020, and Feb 11, 2020. Findings We estimated that the median daily reproduction number (R t) in Wuhan declined from 2·35 (95% CI 1·15–4·77) 1 week before travel restrictions were introduced on Jan 23, 2020, to 1·05 (0·41–2·39) 1 week after. Based on our estimates of R t, assuming SARS-like variation, we calculated that in locations with similar transmission potential to Wuhan in early January, once there are at least four independently introduced cases, there is a more than 50% chance the infection will establish within that population. Interpretation Our results show that COVID-19 transmission probably declined in Wuhan during late January, 2020, coinciding with the introduction of travel control measures. As more cases arrive in international locations with similar transmission potential to Wuhan before these control measures, it is likely many chains of transmission will fail to establish initially, but might lead to new outbreaks eventually. Funding Wellcome Trust, Health Data Research UK, Bill & Melinda Gates Foundation, and National Institute for Health Research.
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              GeoDa: An Introduction to Spatial Data Analysis

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                Author and article information

                Contributors
                devarupagupta140890@gmail.com
                dibyendubiswas92@gmail.com
                pintukabirajs@gmail.com
                Journal
                GeoJournal
                GeoJournal
                Geojournal
                Springer Netherlands (Dordrecht )
                0343-2521
                1572-9893
                3 March 2021
                : 1-19
                Affiliations
                [1 ]GRID grid.419349.2, ISNI 0000 0001 0613 2600, International Institute for Population Sciences, ; Govandi Station Road, Deonar, Mumbai, 400088 Maharashtra India
                [2 ]Institute of Development Studies Kolkata, 27/D, DD Block, Sector 1, Salt Lake, Kolkata, 700064 West Bengal India
                [3 ]Purulia, India
                Author information
                http://orcid.org/0000-0003-2398-1043
                Article
                10394
                10.1007/s10708-021-10394-6
                7925257
                33678946
                0ca92e43-18c4-4dd0-901d-ebadbaa41093
                © The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                : 9 February 2021
                Categories
                Article

                covid-19,urban-centric,cities,modes of transmission,travel networks,spatial regression models

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