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      • Record: found
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      Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Highlights

          • Development of Au nanostar@AIE nanodots photosensitizers for theranostic applications.

          • Achieving excellent metal-enhanced fluorescence and singlet oxygen generation efficiency simultaneously.

          • Mechanism study of the role of FRET on metal-enhanced singlet oxygen generation.

          Supplementary Information

          The online version of this article (10.1007/s40820-020-00583-2) contains supplementary material, which is available to authorized users.

          Abstract

          Dual-functional aggregation-induced photosensitizers (AIE-PSs) with singlet oxygen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the 1O 2 production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest 1O 2 enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal-enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.

          Supplementary Information

          The online version of this article (10.1007/s40820-020-00583-2) contains supplementary material, which is available to authorized users.

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          Most cited references56

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          Optical Constants of the Noble Metals

          P. Johnson, R. Christy (1972)
          Article 0 comments Cited 3243 times – based on 0 reviews     Review now
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            Photodynamic therapy of cancer: An update

            Patrizia Agostinis, Kristian Berg, Keith A. Cengel … (2011)
            Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.
            Article 0 comments Cited 722 times – based on 0 reviews     Review now
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              Fluorescence lifetime measurements and biological imaging.

              Mikhail Y Berezin, Samuel Achilefu (2010)
              Article 0 comments Cited 468 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Bin Liu: cheliub@nus.edu.sg
                Yen Nee Tan: yennee.tan@newcastle.ac.uk
                Journal
                Journal ID (nlm-ta): Nanomicro Lett
                Journal ID (iso-abbrev): Nanomicro Lett
                Title: Nano-Micro Letters
                Publisher: Springer Singapore (Singapore )
                ISSN (Print): 2311-6706
                ISSN (Electronic): 2150-5551
                Publication date (Electronic): 16 January 2021
                Publication date PMC-release: 16 January 2021
                Publication date Collection: December 2021
                Volume: 13
                Electronic Location Identifier: 58
                Affiliations
                [1 ]GRID grid.185448.4, ISNI 0000 0004 0637 0221, Institute of Materials Research and Engineering, , Agency for Science, Technology and Research (A*STAR), ; Singapore, 138634 Singapore
                [2 ]GRID grid.4280.e, ISNI 0000 0001 2180 6431, Department of Chemical and Biomolecular Engineering, , National University of Singapore, ; 4 Engineering Drive 4, Singapore, 117585 Singapore
                [3 ]GRID grid.4280.e, ISNI 0000 0001 2180 6431, Department of Mechanical Engineering, , National University of Singapore, ; 9 Engineering Drive 1, Singapore, 117575 Singapore
                [4 ]GRID grid.1006.7, ISNI 0000 0001 0462 7212, Faculty of Science, Agriculture and Engineering, , Newcastle University, ; Newcastle Upon Tyne, NE1 7RU UK
                [5 ]Newcastle Research and Innovation Institute (NewRIIS), 80 Jurong East Street 21, #05-04, Singapore, 609607 Singapore
                Article
                Publisher ID: 583
                DOI: 10.1007/s40820-020-00583-2
                PMC ID: 8187487
                SO-VID: 0bd959f7-161c-4cd9-a316-2c27776b2bab
                Copyright © © The Author(s) 2021
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 28 October 2020
                Date accepted : 8 December 2020
                Categories
                Subject: Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2021

                Keywords: plasmon enhancement,photosensitizer,aggregation-induced emission,fluorescence imaging,theranostics
                Data availability:
                Keywords: plasmon enhancement, photosensitizer, aggregation-induced emission, fluorescence imaging, theranostics

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